No Worries: Pfizer Still Hides Bad Lipitor Data, But Has More Good Data For You Today
3 CommentsBy Ed Silverman // June 25th, 2007 // 10:39 am
Nearly two weeks ago, Pfizer disclosed in a filing with the Securities and Exchange Commission that there was a mistake in a study publicized last March, which initially showed Lipitor lowered cardiovascular risks. At the time, a press release was issued to tout the results. But this month, the drugmaker refused to similarly issue a press release after discovering the mistake and filing with the SEC, even though docs and managed care decision-makers may not readily hear about the bad news otherwise.
Today, however, Pfizer has no difficulty issuing a press release that - surprise - touts good news about Lipitor. A new analysis of a study published last year in the New England Journal of Medicine found the very high 80 mg dose of the cholesterol pill reduced the risk of stroke, coronary heart disease events and major coronary events in certain type 2 diabetes patients. The results*, which generated debate*, are trumpeted at this week’s American Diabetes Association in Chicago.
This behavior runs counter to the very goals Pfizer ceo Jeff Kindler articulated to Wall Street analysts and fund managers last November, when he spoke of “transparency, candid dialogue, clear accountability.”
So Jeff, what happened? If the marketing team is no longer in charge of everything, why hasn’t Pfizer gotten around to issuing that bad news press release? Your company has had 11 days to correct its mistake. Will that happen, or are accountability and transparency just convenient buzzwords?
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JS
how can we believe anything they say…duh they are so incredibly not credible
Hank
I certainly concur with the big point - that Pfizer should not continue to “closet” (kindest word) the numbers from the SEC-related study that undid the initial hype.
In the meantime, all these announcements are frustrating because they leave out NNT numbers and absolute risk differences. Considering how often Lipitor is touted as a “miracle drug” - and the latest study was for secondary prevention at the highest Lipitor dose that is given, 80 mg, the ideal circumstances for miracles to reveal themselves - how impressive are the relative risk differences is in the mind of the beholder.
In the meantime, as a kind of aside in the latest report, the risk of hemorrhagic stroke was actually _increased_ relative to placebo among patients taking Lipitor. But no numbers are provided on this difference, not even relative risk ones.
Makes one kinda wonder.
Ed
How many doctors actually use 80mg of Lipitor? ANd is it “Lipitor” or the lowering of the ldl that reduces events? Isn’t there some NEW warning in Lipitors PI about the 80mg dose and MI patients?