Comments on: Vioxx Caused Heart Attacks In Two Weeks! http://www.pharmalot.com/2007/07/vioxx-caused-heart-attacks-in-two-weeks/ News, Comment and Conversation Sun, 14 Mar 2010 10:44:03 +0000 http://wordpress.org/?v=2.6.2 By: Ed Silverman http://www.pharmalot.com/2007/07/vioxx-caused-heart-attacks-in-two-weeks/#comment-14739 Ed Silverman Tue, 03 Jul 2007 20:46:01 +0000 http://www.pharmalot.com/2007/07/vioxx-caused-heart-attacks-in-two-weeks/#comment-14739 Hi Peter, I did include that point. If you click on the words 'Read more,' you will see more information along with a comment from Merck's attorney. Cheers ed Hi Peter,

I did include that point. If you click on the words ‘Read more,’ you will see more information along with a comment from Merck’s attorney.

Cheers
ed

]]> By: Peter http://www.pharmalot.com/2007/07/vioxx-caused-heart-attacks-in-two-weeks/#comment-14738 Peter Tue, 03 Jul 2007 20:42:39 +0000 http://www.pharmalot.com/2007/07/vioxx-caused-heart-attacks-in-two-weeks/#comment-14738 One other part of the article that you did not quote is that in this study all the CV effect difference between drg and placebo is attributed to the first 14 days. From what I understand, if the patient did not have an event in the first 14 days, they did not end uyp having one. This may be a blow to all the plaintiffs who claim effects way after patients stopped taking the drug. One other part of the article that you did not quote is that in this study all the CV effect difference between drg and placebo is attributed to the first 14 days. From what I understand, if the patient did not have an event in the first 14 days, they did not end uyp having one.

This may be a blow to all the plaintiffs who claim effects way after patients stopped taking the drug.

]]> By: Reality http://www.pharmalot.com/2007/07/vioxx-caused-heart-attacks-in-two-weeks/#comment-14736 Reality Tue, 03 Jul 2007 19:54:07 +0000 http://www.pharmalot.com/2007/07/vioxx-caused-heart-attacks-in-two-weeks/#comment-14736 Laurie, The study was not stopped because of the events in that study, but stopped after Merck pulled Vioxx after because of results from the Approve study. I haven't seen the results of this study (Victor), but if they already unblinded as they were still getting results, then yes, it does cast doubt on the results. In the same way, if Merck saw something positive after unblinding but still collecting data, people would have a collective fit over the soundness of that data. Laurie,

The study was not stopped because of the events in that study, but stopped after Merck pulled Vioxx after because of results from the Approve study.

I haven’t seen the results of this study (Victor), but if they already unblinded as they were still getting results, then yes, it does cast doubt on the results. In the same way, if Merck saw something positive after unblinding but still collecting data, people would have a collective fit over the soundness of that data.

]]> By: Laurie http://www.pharmalot.com/2007/07/vioxx-caused-heart-attacks-in-two-weeks/#comment-14730 Laurie Tue, 03 Jul 2007 16:21:51 +0000 http://www.pharmalot.com/2007/07/vioxx-caused-heart-attacks-in-two-weeks/#comment-14730 "there were limitations in it related to the premature termination of the study together with the fact that events were collected after patients had been unblinded" Am I getting this? His contention is that since the study ended early, DUE to the problems, those problems shouldn't be included as part of ths study? Wow, talk about spin! “there were limitations in it related to the premature termination of the study together with the fact that events were collected after patients had been unblinded”

Am I getting this? His contention is that since the study ended early, DUE to the problems, those problems shouldn’t be included as part of ths study? Wow, talk about spin!

]]> By: Kent Jarrell http://www.pharmalot.com/2007/07/vioxx-caused-heart-attacks-in-two-weeks/#comment-14725 Kent Jarrell Tue, 03 Jul 2007 13:50:03 +0000 http://www.pharmalot.com/2007/07/vioxx-caused-heart-attacks-in-two-weeks/#comment-14725 I thought you might be interested to see the statement from Ted Mayer, Outside Counsel for Merck in the Vioxx litigation. “We will wait until publication of the study before going into detail about what the data show or do not show. The data have been previously presented last year at a scientific meeting, and at that time it was noted that there were limitations in it related to the premature termination of the study together with the fact that events were collected after patients had been unblinded. The reported findings with respect to confirmed thrombotic events in short - term use are not supported by the data found in the other available large placebo studies with Vioxx , including Alzheimers’ studies, VIP and APPROVe.” I thought you might be interested to see the statement from Ted Mayer, Outside Counsel for Merck in the Vioxx litigation.

“We will wait until publication of the study before going into detail about what the data show or do not show.

The data have been previously presented last year at a scientific meeting, and at that time it was noted that there were limitations in it related to the premature termination of the study together with the fact that events were collected after patients had been unblinded.

The reported findings with respect to confirmed thrombotic events in short - term use are not supported by the data found in the other available large placebo studies with Vioxx , including Alzheimers’ studies, VIP and APPROVe.”

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