Thanks for the information, I had wondered what effects this spray would have on a woman.A numb clitoris is not a good thing.

Pain management for burn victims,…Thats interesting.

While I’ve only been able to read the abstract of their phase II study, it seems that they have reached statistical significance on improving the IELT (time from putting it in to launching a load). However, they did not reach statistical significance on two other measures that I’m sure they wanted to. These were the index of ejaculatory control (IEC) and sexual quality-of-life (SQoL) scores of patients and their partners.

They also only included statistics from two attempts at intercourse in crunching the numbers for their study. I would want to know why only two, and how those two attempts were selected. And while they have some very competent researchers involved, as with any study, I would want to know the financial relationships between the study authors and Plethora Solutions.

In other words, we need to wait until the phase III trials are done to have a better sense of whether this puppy is going to fly. I certainly hope it does, but I also wouldn’t be surprised if they encounter some stiff hurdles ahead.

As we have learned from the large number of men with ED who are helped by Viagra but never get a refill–relationships are complex. There seems to be more to physical intimacy than a penis that gets hard and stays hard for X number of minutes. In addition, there are also different causes of premature ejaculation in different men. For instance, in one guy, there might by a physical hypersensitivity, while anxiety might be fueling the problem in another man. This isn’t to say that the Plethora PE drug won’t help both, but it might be for very different reasons.

I’ve also got to give the marketing people at Plethora their due. Plethora is concurrently developing a “medical device for the objective evaluation of the condition” in order to “promote reimbursable clinical management of the PE sufferer.” In other words, their device attempts to quantify the problem to help you collect from your insurance company.

This seems to be a device that registers the time between erection and ejaculation. On first look, it appears to assume that all men begin intercourse as soon as they become erect. But maybe their device is more sophisticated than the scant bit of information I’ve seen about it. And their device might be helpful in documenting the extent of the problem for those guys who ejaculate shortly after becoming erect with a partner.

As for the discussion here that anti-depressants cause sexual problems, keep in mind that there is more than one type of anti-depressant. For instance, the kind of sexual problem that you often hear associated with SSRIs is delayed orgasm or anorgasmia, while ED might be more associated with trycyclic antidepressants. Again, generalizations don’t always work too well, as clomipramine (Anafranil) is a trycyclic that is sometimes used off-label to help delay ejaculation.

And finally, I couldn’t help but note that another very cool application for the Plethora Solutions PE drug might be for pain management in burn victims who are undergoing skin transplants.

What I am saying is this,Antidepressants can, and do, cause PE & ED.And as I said earlier, this spray may be a godsend to those adults who need their antidepressant medications.

We are talking about adults here,”NOT CHILDREN”

Remember that antidepressants in children lack efficacy…

There ought to be a law! The drug companies are evil. EVIL!

The point is that this preparation may offer an alternative for people who currently turn to off-label use of the very drugs you so strongly protest. One would think you would welcome that development.

Antidepressants and your Libido

http://www.medicinenet.com/script/main/art.asp?articlekey=51118

http://www.nytimes.com/specials/women/warchive/960515_1126.html