Three people have died and several others suffered serious reactions after taking Lamisil, which is used to treat ringworm and nail fungal problems, according to Australia’s Therapeutic Goods Administration. The agency, which notes Lamisil can cause liver problems, received 722 adverse event reports, including 70 liver reactions, and 61 implicated the tablet form as the prime culprit. Half of those affected suffered liver reaction within a month.

“Three (of the reports) describe fatal liver failure, 10 describe hepatitis, and 12 describe jaundice,” according to the TGA’s latest drug reactions bulletin. “Full recovery was noted in 27 reports but 34 cases had not recovered and the outcome is unknown in nine.”

This is the first report linking Lamisil to liver dysfunction but three others dating as far back as 1996 implicate the drug in the blood condition dyscrasia, according to news.com.au. The TGA, which notes the tablet is prescribed when topical treatments don’t work, warns the tablet should only be used as a last resort. A Novartis spokesman tells the site that serious reactions were rare side-effects of oral anti-fungal medications but he agreed with the TGA’s advice.