We have argued that these failures are caused by “Deceptive Imprinting” (Immunol Today. 1994 Oct;15(10):475-8) of the immune system, a combination of a strong immune response, producing an “Original Antigenic sin” effect and the ability of the virus to mutate.
(see Int Rev Immunol. 2004 Sep-Dec;23(5-6):369-81.)
A hallmark of Deceptive Imprinting is the persistence of clonally restricted immune response in infected individuals at the B and T-cell against viral antigens.
I urge that the vaccine failure volunteers in the trials to be tested for such restricted immune responses. This would confirm our prediction of the cause of vaccine failure.

Heinz Kohler