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	<title>Comments on: UK Minister Wants All Antidepressant Trial Data</title>
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	<link>http://www.pharmalot.com/2008/03/uk-minister-wants-all-antidepressant-trial-data/</link>
	<description>News, Comment and Conversation</description>
	<pubDate>Fri, 10 Feb 2012 20:55:39 +0000</pubDate>
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		<title>By: Nathan</title>
		<link>http://www.pharmalot.com/2008/03/uk-minister-wants-all-antidepressant-trial-data/#comment-189480</link>
		<dc:creator>Nathan</dc:creator>
		<pubDate>Wed, 05 Mar 2008 02:34:11 +0000</pubDate>
		<guid isPermaLink="false">http://www.pharmalot.com/2008/03/uk-minister-wants-all-antidepressant-trial-data/#comment-189480</guid>
		<description>pg,
I'm left assuming that you disagree with my statement?  What part do you disagree with?</description>
		<content:encoded><![CDATA[<p>pg,<br />
I&#8217;m left assuming that you disagree with my statement?  What part do you disagree with?</p>
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		<title>By: pg</title>
		<link>http://www.pharmalot.com/2008/03/uk-minister-wants-all-antidepressant-trial-data/#comment-189358</link>
		<dc:creator>pg</dc:creator>
		<pubDate>Wed, 05 Mar 2008 01:20:56 +0000</pubDate>
		<guid isPermaLink="false">http://www.pharmalot.com/2008/03/uk-minister-wants-all-antidepressant-trial-data/#comment-189358</guid>
		<description>You shouldn't have been listening to the Jacks and Nathans of this world. You should have been listening to YOUR CHILD. If you had, she would never have been given drugs, she would have been given what you, as parents, were meant to have given her. Parental love, support and guidance.  Isn't that so?</description>
		<content:encoded><![CDATA[<p>You shouldn&#8217;t have been listening to the Jacks and Nathans of this world. You should have been listening to YOUR CHILD. If you had, she would never have been given drugs, she would have been given what you, as parents, were meant to have given her. Parental love, support and guidance.  Isn&#8217;t that so?</p>
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		<title>By: pg</title>
		<link>http://www.pharmalot.com/2008/03/uk-minister-wants-all-antidepressant-trial-data/#comment-189273</link>
		<dc:creator>pg</dc:creator>
		<pubDate>Wed, 05 Mar 2008 00:45:14 +0000</pubDate>
		<guid isPermaLink="false">http://www.pharmalot.com/2008/03/uk-minister-wants-all-antidepressant-trial-data/#comment-189273</guid>
		<description>We are fighting to protect children. Mostly AMERICAN children because their parents seem unable to understand and put them on drugs then complain when they have adverse drug reactions.   Why do we bother? Who knows? But we will continue to protect european kids from drug companies and parents who have allowed it to happen in the US.</description>
		<content:encoded><![CDATA[<p>We are fighting to protect children. Mostly AMERICAN children because their parents seem unable to understand and put them on drugs then complain when they have adverse drug reactions.   Why do we bother? Who knows? But we will continue to protect european kids from drug companies and parents who have allowed it to happen in the US.</p>
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		<title>By: pg</title>
		<link>http://www.pharmalot.com/2008/03/uk-minister-wants-all-antidepressant-trial-data/#comment-189237</link>
		<dc:creator>pg</dc:creator>
		<pubDate>Wed, 05 Mar 2008 00:30:20 +0000</pubDate>
		<guid isPermaLink="false">http://www.pharmalot.com/2008/03/uk-minister-wants-all-antidepressant-trial-data/#comment-189237</guid>
		<description>"Lisa Van S
Nathan,

I agree,.. well stated"


Well Lisa, thats nice. People like us are trying to protect children, like YOUR children, and you agree with NATHAN? Wow. No wonder you allowed YOUR CHILD to be put on drugs.</description>
		<content:encoded><![CDATA[<p>&#8220;Lisa Van S<br />
Nathan,</p>
<p>I agree,.. well stated&#8221;</p>
<p>Well Lisa, thats nice. People like us are trying to protect children, like YOUR children, and you agree with NATHAN? Wow. No wonder you allowed YOUR CHILD to be put on drugs.</p>
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		<title>By: Matthew Holford</title>
		<link>http://www.pharmalot.com/2008/03/uk-minister-wants-all-antidepressant-trial-data/#comment-188809</link>
		<dc:creator>Matthew Holford</dc:creator>
		<pubDate>Tue, 04 Mar 2008 16:15:32 +0000</pubDate>
		<guid isPermaLink="false">http://www.pharmalot.com/2008/03/uk-minister-wants-all-antidepressant-trial-data/#comment-188809</guid>
		<description>Former pharma Marketing Exec wrote:
"...When the right drug gets to the right patient - well that is what we should all strive for..."

But that's the point, isn't it?  There is precious little provision of psychotherapy (at least in the UK, on the NHS), for those with mild/moderate depression.  If one can't afford it privately, one doesn't get it.  As such, doctors prescribe drugs for conditions for which they are no more effective than therapy.

The Worshipful Company may say "hey, we just make the things, we're not responsible for inappropriate prescribing".  And the quacks may say "hey, we just treat people with the resources available, if there're no counsellors, we prescribe drugs".  And the regulators may say "yes, sir".  Could one of you halfwits actually take responsibility, instead of pretending that the issue isn't yours, because, between you, you've created a mega-sized cluster fuck, and the patients are paying the tab, just now.

Matt</description>
		<content:encoded><![CDATA[<p>Former pharma Marketing Exec wrote:<br />
&#8220;&#8230;When the right drug gets to the right patient - well that is what we should all strive for&#8230;&#8221;</p>
<p>But that&#8217;s the point, isn&#8217;t it?  There is precious little provision of psychotherapy (at least in the UK, on the NHS), for those with mild/moderate depression.  If one can&#8217;t afford it privately, one doesn&#8217;t get it.  As such, doctors prescribe drugs for conditions for which they are no more effective than therapy.</p>
<p>The Worshipful Company may say &#8220;hey, we just make the things, we&#8217;re not responsible for inappropriate prescribing&#8221;.  And the quacks may say &#8220;hey, we just treat people with the resources available, if there&#8217;re no counsellors, we prescribe drugs&#8221;.  And the regulators may say &#8220;yes, sir&#8221;.  Could one of you halfwits actually take responsibility, instead of pretending that the issue isn&#8217;t yours, because, between you, you&#8217;ve created a mega-sized cluster fuck, and the patients are paying the tab, just now.</p>
<p>Matt</p>
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		<title>By: Matthew Holford</title>
		<link>http://www.pharmalot.com/2008/03/uk-minister-wants-all-antidepressant-trial-data/#comment-188800</link>
		<dc:creator>Matthew Holford</dc:creator>
		<pubDate>Tue, 04 Mar 2008 16:08:56 +0000</pubDate>
		<guid isPermaLink="false">http://www.pharmalot.com/2008/03/uk-minister-wants-all-antidepressant-trial-data/#comment-188800</guid>
		<description>Jack2 wrote:
"...The other issue ignored here is cost. Even if therapy worked as well as the drugs, therapy was more expensive than the drugs when the drugs were still on patent. Now that the drugs are generic it’s a landslide cost victory for the drugs..."

Doesn't that depend upon how long a patient is prescribed the drugs (and also the difficulty that a patient might have coming off them)?

Counselling is about changing behaviour, such that a patient not only deals with the current issue, but also avoids recurrences.  A drug can't do that.

Matt</description>
		<content:encoded><![CDATA[<p>Jack2 wrote:<br />
&#8220;&#8230;The other issue ignored here is cost. Even if therapy worked as well as the drugs, therapy was more expensive than the drugs when the drugs were still on patent. Now that the drugs are generic it’s a landslide cost victory for the drugs&#8230;&#8221;</p>
<p>Doesn&#8217;t that depend upon how long a patient is prescribed the drugs (and also the difficulty that a patient might have coming off them)?</p>
<p>Counselling is about changing behaviour, such that a patient not only deals with the current issue, but also avoids recurrences.  A drug can&#8217;t do that.</p>
<p>Matt</p>
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		<title>By: Former pharma Marketing Exec</title>
		<link>http://www.pharmalot.com/2008/03/uk-minister-wants-all-antidepressant-trial-data/#comment-188798</link>
		<dc:creator>Former pharma Marketing Exec</dc:creator>
		<pubDate>Tue, 04 Mar 2008 16:07:00 +0000</pubDate>
		<guid isPermaLink="false">http://www.pharmalot.com/2008/03/uk-minister-wants-all-antidepressant-trial-data/#comment-188798</guid>
		<description>Jack2:

But the real problem is that this study says that the major portion of the patients were not helped any better than with a placebo.  It does say that for those who were seriously depressed there was an effect.  When the right drug gets to the right patient - well that is what we should all strive for.  It's the unnecessary over medicating of people going through mild depressions which by the way, tend to clear up by themselves within 12 weeks without treatment.  For this patients population (which I would imagine is the largest portion)derive no benefit and suffer serious side effects and then become dependent.  That is the real problem.</description>
		<content:encoded><![CDATA[<p>Jack2:</p>
<p>But the real problem is that this study says that the major portion of the patients were not helped any better than with a placebo.  It does say that for those who were seriously depressed there was an effect.  When the right drug gets to the right patient - well that is what we should all strive for.  It&#8217;s the unnecessary over medicating of people going through mild depressions which by the way, tend to clear up by themselves within 12 weeks without treatment.  For this patients population (which I would imagine is the largest portion)derive no benefit and suffer serious side effects and then become dependent.  That is the real problem.</p>
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		<title>By: Jack2</title>
		<link>http://www.pharmalot.com/2008/03/uk-minister-wants-all-antidepressant-trial-data/#comment-188515</link>
		<dc:creator>Jack2</dc:creator>
		<pubDate>Tue, 04 Mar 2008 13:29:22 +0000</pubDate>
		<guid isPermaLink="false">http://www.pharmalot.com/2008/03/uk-minister-wants-all-antidepressant-trial-data/#comment-188515</guid>
		<description>You can call the company.  20% of my job is distributing unpublished studies to HCPs who call to ask for them (I never worked on an SSRIs, or for a company that makes any anti-depressants).  These authors didn't call, so we don't know.  And the level of detail they would have gotten (probably less than 500 words covering the main point), may or may not have been sufficient for a meta-analysis but it would provide a decent summary of the trial.

The other issue ignored here is cost.  Even if therapy worked as well as the drugs, therapy was more expensive than the drugs when the drugs were still on patent.  Now that the drugs are generic it's a landslide cost victory for the drugs.

I know that people here have a lot of strong feelings about SSRIs.  But the papers abstract makes the FDA look ridiculous.  80% of people here may enjoy seeing the FDA look ridiculous; the fact is that this group of authors, with all of its biases, with all of its digging around, still had to admit that antidepressants caused a statistically significant improvement in depression.  Furthermore, their methods may include a lot of irrelevant trials.  If you want to ignore the numbers and just go on your gut reasoning you can, I choose to look at the numbers.</description>
		<content:encoded><![CDATA[<p>You can call the company.  20% of my job is distributing unpublished studies to HCPs who call to ask for them (I never worked on an SSRIs, or for a company that makes any anti-depressants).  These authors didn&#8217;t call, so we don&#8217;t know.  And the level of detail they would have gotten (probably less than 500 words covering the main point), may or may not have been sufficient for a meta-analysis but it would provide a decent summary of the trial.</p>
<p>The other issue ignored here is cost.  Even if therapy worked as well as the drugs, therapy was more expensive than the drugs when the drugs were still on patent.  Now that the drugs are generic it&#8217;s a landslide cost victory for the drugs.</p>
<p>I know that people here have a lot of strong feelings about SSRIs.  But the papers abstract makes the FDA look ridiculous.  80% of people here may enjoy seeing the FDA look ridiculous; the fact is that this group of authors, with all of its biases, with all of its digging around, still had to admit that antidepressants caused a statistically significant improvement in depression.  Furthermore, their methods may include a lot of irrelevant trials.  If you want to ignore the numbers and just go on your gut reasoning you can, I choose to look at the numbers.</p>
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		<title>By: Lisa Van S</title>
		<link>http://www.pharmalot.com/2008/03/uk-minister-wants-all-antidepressant-trial-data/#comment-188467</link>
		<dc:creator>Lisa Van S</dc:creator>
		<pubDate>Tue, 04 Mar 2008 12:45:18 +0000</pubDate>
		<guid isPermaLink="false">http://www.pharmalot.com/2008/03/uk-minister-wants-all-antidepressant-trial-data/#comment-188467</guid>
		<description>Nathan,

I agree,.. well stated.</description>
		<content:encoded><![CDATA[<p>Nathan,</p>
<p>I agree,.. well stated.</p>
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		<title>By: Matthew Holford</title>
		<link>http://www.pharmalot.com/2008/03/uk-minister-wants-all-antidepressant-trial-data/#comment-188460</link>
		<dc:creator>Matthew Holford</dc:creator>
		<pubDate>Tue, 04 Mar 2008 12:34:32 +0000</pubDate>
		<guid isPermaLink="false">http://www.pharmalot.com/2008/03/uk-minister-wants-all-antidepressant-trial-data/#comment-188460</guid>
		<description>Donna wrote:
"...and as I’ve stated before profound change’s are taking place..."

Alert... alert... alert... sarcasm follows:
I don't suppose these profound changes would include the de-criminalization of off-lable marketing, together with the introduction of pre-emption nationally, would they?

Matt
"Be alert: the world needs more lerts."</description>
		<content:encoded><![CDATA[<p>Donna wrote:<br />
&#8220;&#8230;and as I’ve stated before profound change’s are taking place&#8230;&#8221;</p>
<p>Alert&#8230; alert&#8230; alert&#8230; sarcasm follows:<br />
I don&#8217;t suppose these profound changes would include the de-criminalization of off-lable marketing, together with the introduction of pre-emption nationally, would they?</p>
<p>Matt<br />
&#8220;Be alert: the world needs more lerts.&#8221;</p>
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