Comments on: Glaxo Pays $720M For Fountain Of Youth Pill http://www.pharmalot.com/2008/04/glaxo-pays-720m-for-fountain-of-youth-pill/ News, Comment and Conversation Thu, 18 Mar 2010 22:29:12 +0000 http://wordpress.org/?v=2.6.2 By: truthman30 http://www.pharmalot.com/2008/04/glaxo-pays-720m-for-fountain-of-youth-pill/#comment-310348 truthman30 Wed, 23 Apr 2008 15:48:23 +0000 http://www.pharmalot.com/2008/04/glaxo-pays-720m-for-fountain-of-youth-pill/#comment-310348 Interesting.. GSK trying to make an anti-aging pill.. One can only imagine the what the side effects will be? GSK is ingenious when it comes to creating side effects so bizarre that they usually defy medical definition... (google paxil-you will be amazed) Maybe that's their true expertise and forte? Creating imaginative drugs with fantastical side effects for disorders which don't exist and diseases which are not illnesses? Bravo Glaxo.. Interesting..
GSK trying to make an anti-aging pill..
One can only imagine the what the side effects will be?
GSK is ingenious when it comes to creating side effects so bizarre that they usually defy medical definition… (google paxil-you will be amazed)

Maybe that’s their true expertise and forte?
Creating imaginative drugs with fantastical side effects for disorders which don’t exist and diseases which are not illnesses?
Bravo Glaxo..

]]> By: Chris http://www.pharmalot.com/2008/04/glaxo-pays-720m-for-fountain-of-youth-pill/#comment-310033 Chris Wed, 23 Apr 2008 12:48:55 +0000 http://www.pharmalot.com/2008/04/glaxo-pays-720m-for-fountain-of-youth-pill/#comment-310033 It's a very long way from where Sirius is now to getting to market as many here know and so talk of how the public will lap this up is a little premature (but probably accurate). Resveratrol seems to be one of the enzymes referred to as having the anti-aging properties. Remember the fuss caused a couple of years ago when the Harvard study pointed out this is the same stuff (a poyphenol) found in red wine? In the small print was that a human would have to drink 1,500 litres per day to get the same effect as the mouse did. Interested to watch how this translates into human clinicals and whether GSK's rather generous offer pays off. It’s a very long way from where Sirius is now to getting to market as many here know and so talk of how the public will lap this up is a little premature (but probably accurate).

Resveratrol seems to be one of the enzymes referred to as having the anti-aging properties. Remember the fuss caused a couple of years ago when the Harvard study pointed out this is the same stuff (a poyphenol) found in red wine? In the small print was that a human would have to drink 1,500 litres per day to get the same effect as the mouse did.

Interested to watch how this translates into human clinicals and whether GSK’s rather generous offer pays off.

]]> By: Matt http://www.pharmalot.com/2008/04/glaxo-pays-720m-for-fountain-of-youth-pill/#comment-310016 Matt Wed, 23 Apr 2008 12:39:11 +0000 http://www.pharmalot.com/2008/04/glaxo-pays-720m-for-fountain-of-youth-pill/#comment-310016 Doesn't matter if the pill works or not, there will be a huge PR campaign to push the drug and billions will be made because the average consumer is a dullard and will buy anything because there is a commerical for it. (I just wanted to use dullard in a sentence) Doesn’t matter if the pill works or not, there will be a huge PR campaign to push the drug and billions will be made because the average consumer is a dullard and will buy anything because there is a commerical for it.

(I just wanted to use dullard in a sentence)

]]> By: Bob Freeman http://www.pharmalot.com/2008/04/glaxo-pays-720m-for-fountain-of-youth-pill/#comment-309193 Bob Freeman Wed, 23 Apr 2008 04:32:28 +0000 http://www.pharmalot.com/2008/04/glaxo-pays-720m-for-fountain-of-youth-pill/#comment-309193 Hmmm. We need to take a normal biological process, Aging, and define it as a disease and then give it initials so people will be able to talk about it at parties. Initials are also necessary to establish it as a "real" medical condition. Any Ideas for naming the disease? It will work as long as Americans view death as optional. Hmmm. We need to take a normal biological process, Aging, and define it as a disease and then give it initials so people will be able to talk about it at parties. Initials are also necessary to establish it as a “real” medical condition.

Any Ideas for naming the disease?

It will work as long as Americans view death as optional.

]]> By: Phed-Up http://www.pharmalot.com/2008/04/glaxo-pays-720m-for-fountain-of-youth-pill/#comment-309157 Phed-Up Wed, 23 Apr 2008 04:06:31 +0000 http://www.pharmalot.com/2008/04/glaxo-pays-720m-for-fountain-of-youth-pill/#comment-309157 Yikes....their "drugs" don;t even work the way they claim!!! GSK internal data refutes their MOA's. HOLY SHIT!!!! Yikes….their “drugs” don;t even work the way they claim!!!
GSK internal data refutes their MOA’s.
HOLY SHIT!!!!

]]> By: joe johnson http://www.pharmalot.com/2008/04/glaxo-pays-720m-for-fountain-of-youth-pill/#comment-308610 joe johnson Tue, 22 Apr 2008 23:51:40 +0000 http://www.pharmalot.com/2008/04/glaxo-pays-720m-for-fountain-of-youth-pill/#comment-308610 I heard that Sirtris "pill" is big as a banana and take a long time to digest. Hope they have good follow-ons hahah Do they even have patent coverage on resveratrol? Amazing deal, $720M for a mediocre pill in Ph 2, and no FTO. Big Pharma is very desperate, and Chris and his wife are a good PR team. I Think Sirtris will shelfed as Esperion in 1 year. I heard that Sirtris “pill” is big as a banana and take a long time to digest. Hope they have good follow-ons hahah

Do they even have patent coverage on resveratrol?

Amazing deal, $720M for a mediocre pill in Ph 2, and no FTO.

Big Pharma is very desperate, and Chris and his wife are a good PR team.

I Think Sirtris will shelfed as Esperion in 1 year.

]]> By: Doug Bremner http://www.pharmalot.com/2008/04/glaxo-pays-720m-for-fountain-of-youth-pill/#comment-308534 Doug Bremner Tue, 22 Apr 2008 23:30:44 +0000 http://www.pharmalot.com/2008/04/glaxo-pays-720m-for-fountain-of-youth-pill/#comment-308534 Nervousness about maintaining an erection and not having early ejaculation is not an indication for the FDA but that didn't stop the covert (if not overt) marketing of Viagra and Cialis for those reasons to healthy young men. I guess the point is they need to find something to get it over the FDA threshold, and then they can go bananas with implied messages about aging. They should team up with vitamin and supplement companies like 'Life Extension'. They have already written monograms about what to do once they have helped people live forever. I for one think that would be boring. Maybe they could partner with them and make a combined DHEA drug for immortality. Nervousness about maintaining an erection and not having early ejaculation is not an indication for the FDA but that didn’t stop the covert (if not overt) marketing of Viagra and Cialis for those reasons to healthy young men. I guess the point is they need to find something to get it over the FDA threshold, and then they can go bananas with implied messages about aging. They should team up with vitamin and supplement companies like ‘Life Extension’. They have already written monograms about what to do once they have helped people live forever. I for one think that would be boring.

Maybe they could partner with them and make a combined DHEA drug for immortality.

]]> By: Eben Tessari http://www.pharmalot.com/2008/04/glaxo-pays-720m-for-fountain-of-youth-pill/#comment-308314 Eben Tessari Tue, 22 Apr 2008 22:34:28 +0000 http://www.pharmalot.com/2008/04/glaxo-pays-720m-for-fountain-of-youth-pill/#comment-308314 Glaxo paid an 84% premium for a company with a fantastic PR firm and one marginal compound that just started phase 2 development. The facts are these: - The target has not been shown to increase lifespan in any normal mammals - There are many sirtuins... activating only SIRT1 has not been shown to do anything in mammals - Some data in yeast show activating SIRTs actually decreases lifespan - There is much data to suggest resveratrol doesn't work through sirtuins at all - "Aging" is not a disease recognized by the FDA so there should to be a mechanistic reason for choosing an alternate indication (such as diabetes). -The compound FAILED the only test the FDA cares about for the type-2 diabetes indication: reduction in HbA1c!! Glaxo paid an 84% premium for a company with a fantastic PR firm and one marginal compound that just started phase 2 development. The facts are these:

- The target has not been shown to increase lifespan in any normal mammals

- There are many sirtuins… activating only SIRT1 has not been shown to do anything in mammals

- Some data in yeast show activating SIRTs actually decreases lifespan

- There is much data to suggest resveratrol doesn’t work through sirtuins at all

- “Aging” is not a disease recognized by the FDA so there should to be a mechanistic reason for choosing an alternate indication (such as diabetes).

-The compound FAILED the only test the FDA cares about for the type-2 diabetes indication: reduction in HbA1c!!

]]> By: Ed Silverman http://www.pharmalot.com/2008/04/glaxo-pays-720m-for-fountain-of-youth-pill/#comment-308179 Ed Silverman Tue, 22 Apr 2008 21:43:07 +0000 http://www.pharmalot.com/2008/04/glaxo-pays-720m-for-fountain-of-youth-pill/#comment-308179 Thanks. Sometimes, I move too quickly. I could use that pill about now. ed Thanks. Sometimes, I move too quickly. I could use that pill about now.

ed

]]> By: spelling http://www.pharmalot.com/2008/04/glaxo-pays-720m-for-fountain-of-youth-pill/#comment-308140 spelling Tue, 22 Apr 2008 21:27:26 +0000 http://www.pharmalot.com/2008/04/glaxo-pays-720m-for-fountain-of-youth-pill/#comment-308140 you spelled sirtis wrong you spelled sirtis wrong

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