Neither the Pfizer painkiller of Naproxen, the widely used generic most often sold as Aleve, prevent deterioration of memory and reasoning in older adults with a family history of Alzheimer’s disease, according to a study in the Archives of Neurology.

The findings contradict previous research that suggested the anti-inflammatory pills may indeed help prevent or treat the loss of memory and function of Alzheimer’s. Now, though, patients shouldn’t take the meds for Alzheimer’s because there is no benefit and they pose a risk to the heart, the authors write. Past research shows Celebrex increases the chance of heart attack and stroke at higher doses.

“At this point in time, we don’t suggest using anti- inflammatory drugs for the prevention of Alzheimer’s disease,” Barbara Marin, an associate professor of epidemiology at Johns Hopkins University and an author of the study, tells Bloomberg News. “We are hoping to follow people to see if there are any long-term effects.”

Inflammation has been seen in the brains of Alzheimer’s patients, prompting neurologists and others to speculate that reducing inflammation might reverse or prevent the symptoms of the disease. But patients naproxen faired worse than those on a placebo, suggesting the drug may speed memory deterioration, though further study is needed to determine a definitive link, the researchers write.

The study was paid for with a grant from the National Institute on Aging and stopped early after an increased number of patients on Celebrex had heart attacks or strokes in other studies. Patient were taking 200 milligrams of Celebrex twice a day, more than double the most common dosage.