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	<title>Comments on: Who&#8217;s Delusional? A University Doc &#038; A Clinical Trial</title>
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	<description>News, Comment and Conversation</description>
	<pubDate>Fri, 19 Mar 2010 07:40:35 +0000</pubDate>
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		<item>
		<title>By: AA</title>
		<link>http://www.pharmalot.com/2008/05/whos-delusional-a-university-doc-a-clinical-trial/#comment-357754</link>
		<dc:creator>AA</dc:creator>
		<pubDate>Mon, 02 Jun 2008 20:49:49 +0000</pubDate>
		<guid isPermaLink="false">http://www.pharmalot.com/?p=13686#comment-357754</guid>
		<description>Mary and Anne,

My deepest sympathies also for the loss of your sons.   As one who is tapering from psych meds due to horrific side effects, including a hearing loss, I can't imagine what you must be feeling.   

Please don't stop seeking the truth.

AA</description>
		<content:encoded><![CDATA[<p>Mary and Anne,</p>
<p>My deepest sympathies also for the loss of your sons.   As one who is tapering from psych meds due to horrific side effects, including a hearing loss, I can&#8217;t imagine what you must be feeling.   </p>
<p>Please don&#8217;t stop seeking the truth.</p>
<p>AA</p>
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		<title>By: Anne</title>
		<link>http://www.pharmalot.com/2008/05/whos-delusional-a-university-doc-a-clinical-trial/#comment-357739</link>
		<dc:creator>Anne</dc:creator>
		<pubDate>Mon, 02 Jun 2008 18:05:32 +0000</pubDate>
		<guid isPermaLink="false">http://www.pharmalot.com/?p=13686#comment-357739</guid>
		<description>Mary, all my condolences to you.  I lost my son as well, killed by the Lilly atypical antipsychotic Zyprexa.  As was learned later, the company knew of its lethal effects, namely diabetes, hyperglycemia, and death.  My son died of profound hyperglycemia - we, of course, had no inkling of the peril.

I will go to my grave seeking real justice for those bottom liners at Lilly who hid this evidence.  Real justice for them is long prison terms.

If you wish to correspond, please get my email from Ed.</description>
		<content:encoded><![CDATA[<p>Mary, all my condolences to you.  I lost my son as well, killed by the Lilly atypical antipsychotic Zyprexa.  As was learned later, the company knew of its lethal effects, namely diabetes, hyperglycemia, and death.  My son died of profound hyperglycemia - we, of course, had no inkling of the peril.</p>
<p>I will go to my grave seeking real justice for those bottom liners at Lilly who hid this evidence.  Real justice for them is long prison terms.</p>
<p>If you wish to correspond, please get my email from Ed.</p>
]]></content:encoded>
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		<title>By: Edwina C</title>
		<link>http://www.pharmalot.com/2008/05/whos-delusional-a-university-doc-a-clinical-trial/#comment-357731</link>
		<dc:creator>Edwina C</dc:creator>
		<pubDate>Mon, 02 Jun 2008 17:51:32 +0000</pubDate>
		<guid isPermaLink="false">http://www.pharmalot.com/?p=13686#comment-357731</guid>
		<description>This article reads like a horror story from the Third Reich.

A Top Psychiatrist Conducts Illegal Experiments on Mental Patients. 

Good Lord, have Mercy.

Sixty years ago, and the likes of Olson would have been shoveling the feeble minded into the gas chambers at Belsen.

Plus ca change..</description>
		<content:encoded><![CDATA[<p>This article reads like a horror story from the Third Reich.</p>
<p>A Top Psychiatrist Conducts Illegal Experiments on Mental Patients. </p>
<p>Good Lord, have Mercy.</p>
<p>Sixty years ago, and the likes of Olson would have been shoveling the feeble minded into the gas chambers at Belsen.</p>
<p>Plus ca change..</p>
]]></content:encoded>
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		<title>By: Lisa Van S</title>
		<link>http://www.pharmalot.com/2008/05/whos-delusional-a-university-doc-a-clinical-trial/#comment-357312</link>
		<dc:creator>Lisa Van S</dc:creator>
		<pubDate>Sun, 25 May 2008 23:00:25 +0000</pubDate>
		<guid isPermaLink="false">http://www.pharmalot.com/?p=13686#comment-357312</guid>
		<description>Mary,... My Deepest Sympathy to you for the loss of your son.</description>
		<content:encoded><![CDATA[<p>Mary,&#8230; My Deepest Sympathy to you for the loss of your son.</p>
]]></content:encoded>
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		<title>By: Lisa Van S</title>
		<link>http://www.pharmalot.com/2008/05/whos-delusional-a-university-doc-a-clinical-trial/#comment-357311</link>
		<dc:creator>Lisa Van S</dc:creator>
		<pubDate>Sun, 25 May 2008 22:58:25 +0000</pubDate>
		<guid isPermaLink="false">http://www.pharmalot.com/?p=13686#comment-357311</guid>
		<description>Ed,

What isnt mentioned here, is that in 2006, FDA placed a Black Box Waring on Seroquel for increased risk of Suicide/Violence.</description>
		<content:encoded><![CDATA[<p>Ed,</p>
<p>What isnt mentioned here, is that in 2006, FDA placed a Black Box Waring on Seroquel for increased risk of Suicide/Violence.</p>
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		<title>By: Ed Silverman</title>
		<link>http://www.pharmalot.com/2008/05/whos-delusional-a-university-doc-a-clinical-trial/#comment-357298</link>
		<dc:creator>Ed Silverman</dc:creator>
		<pubDate>Sun, 25 May 2008 14:02:15 +0000</pubDate>
		<guid isPermaLink="false">http://www.pharmalot.com/?p=13686#comment-357298</guid>
		<description>Hi Mary,

You're welcome. Your son's plight was a compelling tale and one that I thought others would want to read. And thanks for writing in and sharing the additional details. 

I'm sorry about what occurred, but hope he left with you enough pleasant memories. 

All best,
ed</description>
		<content:encoded><![CDATA[<p>Hi Mary,</p>
<p>You&#8217;re welcome. Your son&#8217;s plight was a compelling tale and one that I thought others would want to read. And thanks for writing in and sharing the additional details. </p>
<p>I&#8217;m sorry about what occurred, but hope he left with you enough pleasant memories. </p>
<p>All best,<br />
ed</p>
]]></content:encoded>
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		<title>By: Mary Weiss, mother of Dan</title>
		<link>http://www.pharmalot.com/2008/05/whos-delusional-a-university-doc-a-clinical-trial/#comment-357295</link>
		<dc:creator>Mary Weiss, mother of Dan</dc:creator>
		<pubDate>Sun, 25 May 2008 06:55:02 +0000</pubDate>
		<guid isPermaLink="false">http://www.pharmalot.com/?p=13686#comment-357295</guid>
		<description>Thank you for posting information from the articles that appeared in the St. Paul Pioneer Press May 18, 19 &#38; 20 regarding the death of my son, Dan Markingson.  I would like to add one important item, however, that comes from an entry in Dan's hospital file the second day in the hospital, Nov. 13, 2003. I do not believe the reporters had access to Dan's hospital file.  I, of course, did not either until after Dan's death.  Dr. Olson wrote on Nov 13:

   "However, his grandiosity, the recent sleep disturbance, and somehwhat increased self-esteem even present now also raise the question of bipolar disorder.  If in fact he is really better now and not just concealing the full extent of his delusional thinking, the rapid response to a single dose of Ativan would lean in favor of bipolar disorder."  

There was nothing in the hospital file after that point changing the diagnosis, so Dr. Olson put someone he believed to have bipolar disorder into his study for schizophrenia.  Why?  There was no clinical study for bipolar disorder at that time.  Jeannie Kenney, the study coordinator, however, a licensed social worker, diagnosed Dan as schizophrenic on Page One of the 70 page screening.  On page one, without the screening even having been completed, the question is posed, what do you think the likely diagnosis is?  Based on what?  The color of his eyes, his height? 

Even if Dan had schizophrenia, even for those who do, the drugs themselves cause brain damage.  Google "should neuroleptic drugs be banned" written by a Swedish psychiatrist Lars Martensson.  It gives a very comprehensive explanation of just how they affect the brain.  Thank you.</description>
		<content:encoded><![CDATA[<p>Thank you for posting information from the articles that appeared in the St. Paul Pioneer Press May 18, 19 &amp; 20 regarding the death of my son, Dan Markingson.  I would like to add one important item, however, that comes from an entry in Dan&#8217;s hospital file the second day in the hospital, Nov. 13, 2003. I do not believe the reporters had access to Dan&#8217;s hospital file.  I, of course, did not either until after Dan&#8217;s death.  Dr. Olson wrote on Nov 13:</p>
<p>   &#8220;However, his grandiosity, the recent sleep disturbance, and somehwhat increased self-esteem even present now also raise the question of bipolar disorder.  If in fact he is really better now and not just concealing the full extent of his delusional thinking, the rapid response to a single dose of Ativan would lean in favor of bipolar disorder.&#8221;  </p>
<p>There was nothing in the hospital file after that point changing the diagnosis, so Dr. Olson put someone he believed to have bipolar disorder into his study for schizophrenia.  Why?  There was no clinical study for bipolar disorder at that time.  Jeannie Kenney, the study coordinator, however, a licensed social worker, diagnosed Dan as schizophrenic on Page One of the 70 page screening.  On page one, without the screening even having been completed, the question is posed, what do you think the likely diagnosis is?  Based on what?  The color of his eyes, his height? </p>
<p>Even if Dan had schizophrenia, even for those who do, the drugs themselves cause brain damage.  Google &#8220;should neuroleptic drugs be banned&#8221; written by a Swedish psychiatrist Lars Martensson.  It gives a very comprehensive explanation of just how they affect the brain.  Thank you.</p>
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		<title>By: ol cranky</title>
		<link>http://www.pharmalot.com/2008/05/whos-delusional-a-university-doc-a-clinical-trial/#comment-357042</link>
		<dc:creator>ol cranky</dc:creator>
		<pubDate>Mon, 19 May 2008 23:14:41 +0000</pubDate>
		<guid isPermaLink="false">http://www.pharmalot.com/?p=13686#comment-357042</guid>
		<description>You seem to be making the assumption that clinical trials conducted at academic research centers is somehow better, more ethical and/or higher quality than the work done in non academic institutions.  I can tell you for a fact that this is far from the case.  In general,the KOLs at academic centers are even bigger pigs than those in private practice or at clinical research centers.  Not only are these PIs often disengaged (at best), they also tend not to adhere to protocols and demand payments well in excess of FMV.   In other words, gluttony abounds when it comes to physicians who are KOLs or too cozy a relationship with pharmaceutical companies.</description>
		<content:encoded><![CDATA[<p>You seem to be making the assumption that clinical trials conducted at academic research centers is somehow better, more ethical and/or higher quality than the work done in non academic institutions.  I can tell you for a fact that this is far from the case.  In general,the KOLs at academic centers are even bigger pigs than those in private practice or at clinical research centers.  Not only are these PIs often disengaged (at best), they also tend not to adhere to protocols and demand payments well in excess of FMV.   In other words, gluttony abounds when it comes to physicians who are KOLs or too cozy a relationship with pharmaceutical companies.</p>
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		<title>By: Dan</title>
		<link>http://www.pharmalot.com/2008/05/whos-delusional-a-university-doc-a-clinical-trial/#comment-356985</link>
		<dc:creator>Dan</dc:creator>
		<pubDate>Mon, 19 May 2008 11:06:56 +0000</pubDate>
		<guid isPermaLink="false">http://www.pharmalot.com/?p=13686#comment-356985</guid>
		<description>The Human Injury of Lost Objectivity

If I were to rate the corruptive tactics performed by big pharmaceutical companies, the intentional corruption of implementing fabricated and unreliable results of clinical trials by pharmaceutical companies who manipulate these trials they sponsor because of their power to control others involved in such trials that is largely absent of regulation would be at the top of the list, and likely the most damaging to the requirement of authenticity and, more importantly, assuring the safety of the public health.

Decades ago, clinical trials were conducted at academic settings that focused on the acquisition of knowledge and the completely objective discoveries of meds.  Then, in 1980, the Bayh-Dole Act was created, which allowed for such places to profit off of their discoveries that were performed for pharmaceutical companies in the past.  This resulted in the creation of for-profit research trial sites, called Contract Research Organizations, which is often composed of community research sites with questionable investigators possibly void of necessary research experience or quality regarding their research purpose and ability.  Since they are for- profit, with some CROs making billions of dollars a year. The trials conducted at such places are sponsored by pharmaceutical companies that control and manipulate all aspects of the trial being conducted involving their med being studied in the trial.  This coercion is done by various methods of deception in subtle and tacit methods.  As a result, research in this manner has been transformed into a method of marketing, which includes altered results of the trial to favor the sponsor’s med.  Their activities are absent of true or applied regulation, and therefore have the autonomy to create whatever they want to benefit what may be a collusive relationship between the site and the sponsor.

Further disturbing is that once the creation of the trials is completed, they are then written by ghostwriters often, although no one seems to know how often.  These people are not identified and acknowledged by the sponsor, and may not be trained in clinical research overall, as they are simply freelance writers, as one does not need research training or certification in order to perform this function.  Rarely do trial ghostwriters question their instructions about their assignment, which is clearly deceptive and undocumented, as the mystery writers are known to make about 100 grand a year.  This activity removes accountability and authenticity of the possibly fabricated clinical trial even further.  The corruptive act is finally completed by the sponsor hiring an author to be placed on the trial that likely had no involvement with the trial, and, along with others, was paid by the sponsor for doing this deceptive act. 

 To have the trial published, the sponsor pays a journal to do this, along with the promise of purchasing thousands of reprints of their study from the journal.  Again, how often this process is performed is unknown, yet frequent enough to create hundreds of such false writers and research sites to support the pharmaceutical industry.  So benefits of meds studied in such a malicious way potentially can harm patients and their treatment options and safety risks.  The purchased reprints are distributed to the sponsor’s sales force to share the content with prescribers.
Such misconduct discussed so far impedes research and the scientific method with frightening ethical and harmful concerns.  Our health care treatment with meds is now undetermined in large part with such corruptive situations, as well as the possible absence of objectivity that has been intentionally eliminated.  Trust in the scientific method in this type of activity illustrated in this article is absent.  More now than ever, meds are removed from the market are given black box warnings.  Now I understand why this is occurring.

Transparency and disclosure needs to happen with the pharmaceutical industry for reasons such as this as well as many others, in order to correct what we have historically relied upon for conclusive proof, which is the scientific method.  More importantly, research should not be conducted in a way that the sponsor can interfere in such ways described in this article, requiring independent sites with no involvement with the drug maker.  And clearly, regulation has to be enforced not selectively, but in a complete fashion regarding such matters.  Public awareness would be a catalyst for this to occur, after initially experiencing a state of total disbelief that such operations actually are conducted by such people, of course.  We can no longer be dependent on others for our optimal health.  Knowledge is power, and is also possibly a lifesaver.  


“Ethics and Science need to shake hands.” ……. Richard Cabot



Dan Abshear</description>
		<content:encoded><![CDATA[<p>The Human Injury of Lost Objectivity</p>
<p>If I were to rate the corruptive tactics performed by big pharmaceutical companies, the intentional corruption of implementing fabricated and unreliable results of clinical trials by pharmaceutical companies who manipulate these trials they sponsor because of their power to control others involved in such trials that is largely absent of regulation would be at the top of the list, and likely the most damaging to the requirement of authenticity and, more importantly, assuring the safety of the public health.</p>
<p>Decades ago, clinical trials were conducted at academic settings that focused on the acquisition of knowledge and the completely objective discoveries of meds.  Then, in 1980, the Bayh-Dole Act was created, which allowed for such places to profit off of their discoveries that were performed for pharmaceutical companies in the past.  This resulted in the creation of for-profit research trial sites, called Contract Research Organizations, which is often composed of community research sites with questionable investigators possibly void of necessary research experience or quality regarding their research purpose and ability.  Since they are for- profit, with some CROs making billions of dollars a year. The trials conducted at such places are sponsored by pharmaceutical companies that control and manipulate all aspects of the trial being conducted involving their med being studied in the trial.  This coercion is done by various methods of deception in subtle and tacit methods.  As a result, research in this manner has been transformed into a method of marketing, which includes altered results of the trial to favor the sponsor’s med.  Their activities are absent of true or applied regulation, and therefore have the autonomy to create whatever they want to benefit what may be a collusive relationship between the site and the sponsor.</p>
<p>Further disturbing is that once the creation of the trials is completed, they are then written by ghostwriters often, although no one seems to know how often.  These people are not identified and acknowledged by the sponsor, and may not be trained in clinical research overall, as they are simply freelance writers, as one does not need research training or certification in order to perform this function.  Rarely do trial ghostwriters question their instructions about their assignment, which is clearly deceptive and undocumented, as the mystery writers are known to make about 100 grand a year.  This activity removes accountability and authenticity of the possibly fabricated clinical trial even further.  The corruptive act is finally completed by the sponsor hiring an author to be placed on the trial that likely had no involvement with the trial, and, along with others, was paid by the sponsor for doing this deceptive act. </p>
<p> To have the trial published, the sponsor pays a journal to do this, along with the promise of purchasing thousands of reprints of their study from the journal.  Again, how often this process is performed is unknown, yet frequent enough to create hundreds of such false writers and research sites to support the pharmaceutical industry.  So benefits of meds studied in such a malicious way potentially can harm patients and their treatment options and safety risks.  The purchased reprints are distributed to the sponsor’s sales force to share the content with prescribers.<br />
Such misconduct discussed so far impedes research and the scientific method with frightening ethical and harmful concerns.  Our health care treatment with meds is now undetermined in large part with such corruptive situations, as well as the possible absence of objectivity that has been intentionally eliminated.  Trust in the scientific method in this type of activity illustrated in this article is absent.  More now than ever, meds are removed from the market are given black box warnings.  Now I understand why this is occurring.</p>
<p>Transparency and disclosure needs to happen with the pharmaceutical industry for reasons such as this as well as many others, in order to correct what we have historically relied upon for conclusive proof, which is the scientific method.  More importantly, research should not be conducted in a way that the sponsor can interfere in such ways described in this article, requiring independent sites with no involvement with the drug maker.  And clearly, regulation has to be enforced not selectively, but in a complete fashion regarding such matters.  Public awareness would be a catalyst for this to occur, after initially experiencing a state of total disbelief that such operations actually are conducted by such people, of course.  We can no longer be dependent on others for our optimal health.  Knowledge is power, and is also possibly a lifesaver.  </p>
<p>“Ethics and Science need to shake hands.” ……. Richard Cabot</p>
<p>Dan Abshear</p>
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