Comments on: Sanofi Heart Drug Worsens Heart Failure http://www.pharmalot.com/2008/06/sanofi-heart-drug-worsens-heart-failure/ News, Comment and Conversation Fri, 10 Feb 2012 22:02:04 +0000 http://wordpress.org/?v=2.6.2 By: Lili http://www.pharmalot.com/2008/06/sanofi-heart-drug-worsens-heart-failure/#comment-361938 Lili Fri, 20 Jun 2008 02:57:49 +0000 http://www.pharmalot.com/?p=14198#comment-361938 To Nathan, What gives you the right to give your opinuion? Doctors should treat patients as idviduals,we are all different. Many people have adverse side effects that are nor reported. Medications are not always the answer. More studies should be conducted on preventive medicine. To Nathan,
What gives you the right to give your opinuion? Doctors should treat patients as idviduals,we are all different. Many people have adverse side effects that are nor reported. Medications are not always the answer.
More studies should be conducted on preventive medicine.

]]> By: Ed Silverman http://www.pharmalot.com/2008/06/sanofi-heart-drug-worsens-heart-failure/#comment-361719 Ed Silverman Thu, 19 Jun 2008 14:10:33 +0000 http://www.pharmalot.com/?p=14198#comment-361719 Hi Nathan, Good point. I've altered the headline. As to tough sell, we'll have to see, depending upon the patient population deemed to most need whatever benefit is offered. Regards ed Hi Nathan,

Good point. I’ve altered the headline. As to tough sell, we’ll have to see, depending upon the patient population deemed to most need whatever benefit is offered.

Regards
ed

]]> By: Nathan http://www.pharmalot.com/2008/06/sanofi-heart-drug-worsens-heart-failure/#comment-361716 Nathan Thu, 19 Jun 2008 14:01:58 +0000 http://www.pharmalot.com/?p=14198#comment-361716 It may or may not be a tough sell. The 2007 study of this drug (N Engl J Med 357: 987–999) showed it to slow the recurrence of atrial fibrillation from 52 days (placebo) to 116 days (drug). In this trial (~1400 people), 22.8% of patients in the dronedarone group had been hospitalized or had died at 12 months, as compared with 30.9% of those in the placebo group. The rate of actual death was comparable -- about 1% in each group. The currently available drug for this condition has significant tox issues. The title of the article "Sanofi Heart Drug Causes Heart Failure" isn't accurate. It appears to cause heart failure in patients who already had a severe heart failure. Based on the NEJM article above, the same does NOT appear to be true for less serious events. It may or may not be a tough sell. The 2007 study of this drug (N Engl J Med 357: 987–999) showed it to slow the recurrence of atrial fibrillation from 52 days (placebo) to 116 days (drug). In this trial (~1400 people), 22.8% of patients in the dronedarone group had been hospitalized or had died at 12 months, as compared with 30.9% of those in the placebo group. The rate of actual death was comparable — about 1% in each group. The currently available drug for this condition has significant tox issues.

The title of the article “Sanofi Heart Drug Causes Heart Failure” isn’t accurate. It appears to cause heart failure in patients who already had a severe heart failure. Based on the NEJM article above, the same does NOT appear to be true for less serious events.

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