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	<title>Comments on: Cholesterol Meds For The Youngest Children?</title>
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	<description>News, Comment and Conversation</description>
	<pubDate>Fri, 10 Feb 2012 20:17:26 +0000</pubDate>
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		<title>By: Margaret</title>
		<link>http://www.pharmalot.com/2008/07/cholesterol-meds-for-the-youngest-children/#comment-366412</link>
		<dc:creator>Margaret</dc:creator>
		<pubDate>Sat, 12 Jul 2008 12:24:42 +0000</pubDate>
		<guid isPermaLink="false">http://www.pharmalot.com/?p=14487#comment-366412</guid>
		<description>Anyone bother to look at their evidence for these guidelines?

What these bozos have done is make the wild assed assumption that if you use measures used in adults for secondary prevention of CVD in children it will prevent future CVD without  shred of evidence that the proposed strategy has more benefit than harm. All of the evidence cited in their report was either from studies on adults or children with FH (genetic familial hypercholesterolemia) and none on norml healthy children.

Primary prevention strategies in adults haven't proven very successful so - what the hell - let's try it on our children anyway?

The people who wrote these guidelines are nuts, and any doc that follows them is braindead.</description>
		<content:encoded><![CDATA[<p>Anyone bother to look at their evidence for these guidelines?</p>
<p>What these bozos have done is make the wild assed assumption that if you use measures used in adults for secondary prevention of CVD in children it will prevent future CVD without  shred of evidence that the proposed strategy has more benefit than harm. All of the evidence cited in their report was either from studies on adults or children with FH (genetic familial hypercholesterolemia) and none on norml healthy children.</p>
<p>Primary prevention strategies in adults haven&#8217;t proven very successful so - what the hell - let&#8217;s try it on our children anyway?</p>
<p>The people who wrote these guidelines are nuts, and any doc that follows them is braindead.</p>
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		<title>By: DaisyPatch</title>
		<link>http://www.pharmalot.com/2008/07/cholesterol-meds-for-the-youngest-children/#comment-366363</link>
		<dc:creator>DaisyPatch</dc:creator>
		<pubDate>Fri, 11 Jul 2008 22:06:29 +0000</pubDate>
		<guid isPermaLink="false">http://www.pharmalot.com/?p=14487#comment-366363</guid>
		<description>On another topic - wish the guidelines contained a reference to supplementing the children's statin dosage with coenzyme Q10.
DaisyPatch</description>
		<content:encoded><![CDATA[<p>On another topic - wish the guidelines contained a reference to supplementing the children&#8217;s statin dosage with coenzyme Q10.<br />
DaisyPatch</p>
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		<title>By: Justice in MI</title>
		<link>http://www.pharmalot.com/2008/07/cholesterol-meds-for-the-youngest-children/#comment-366194</link>
		<dc:creator>Justice in MI</dc:creator>
		<pubDate>Thu, 10 Jul 2008 03:21:25 +0000</pubDate>
		<guid isPermaLink="false">http://www.pharmalot.com/?p=14487#comment-366194</guid>
		<description>Atlex - Yes, I was aware of your phrasing which is why I framed my comment as did -- those circumstances (specific but, in my view, not trivial) when Lilli's perspective was, indeed, of direct relevance.</description>
		<content:encoded><![CDATA[<p>Atlex - Yes, I was aware of your phrasing which is why I framed my comment as did &#8212; those circumstances (specific but, in my view, not trivial) when Lilli&#8217;s perspective was, indeed, of direct relevance.</p>
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		<title>By: Atlex</title>
		<link>http://www.pharmalot.com/2008/07/cholesterol-meds-for-the-youngest-children/#comment-366120</link>
		<dc:creator>Atlex</dc:creator>
		<pubDate>Wed, 09 Jul 2008 12:08:43 +0000</pubDate>
		<guid isPermaLink="false">http://www.pharmalot.com/?p=14487#comment-366120</guid>
		<description>JiM,

Note that I specifically stated "statins currently on the market."  Except, perhaps, for Crestor, all statins on the have long term safety records worldwide.  Certainly Bayer did its best to hide data, but the product was still relatively new to the market when it became evident to outsiders that something was amiss.  The other products have been scrutinize by many, many 3rd parties which have continued to demonstrate broad general safety.

Atlex</description>
		<content:encoded><![CDATA[<p>JiM,</p>
<p>Note that I specifically stated &#8220;statins currently on the market.&#8221;  Except, perhaps, for Crestor, all statins on the have long term safety records worldwide.  Certainly Bayer did its best to hide data, but the product was still relatively new to the market when it became evident to outsiders that something was amiss.  The other products have been scrutinize by many, many 3rd parties which have continued to demonstrate broad general safety.</p>
<p>Atlex</p>
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		<title>By: Justice in MI</title>
		<link>http://www.pharmalot.com/2008/07/cholesterol-meds-for-the-youngest-children/#comment-366096</link>
		<dc:creator>Justice in MI</dc:creator>
		<pubDate>Wed, 09 Jul 2008 02:41:29 +0000</pubDate>
		<guid isPermaLink="false">http://www.pharmalot.com/?p=14487#comment-366096</guid>
		<description>Atlex - At core I agree with what you write.  But how do _you_ understand the Baycol saga?  Clearly (so it seems to me), Bayer was able to run the string for a few years through spin, delay, denial, and suppressed internal studies.  Eventually, they ran out of places to hide.  But it took a few years, and it took a few people with them.

So, while I would not generalize to statins as a whole, there are clearly instances that support Lilli's contention that "truth and honesty" really do make a difference, and all those studies are _not_ enough - in themselves - to keep us/docs informed.

They make a helluva difference if your life happens to be part of someone else's "cost of doing business."</description>
		<content:encoded><![CDATA[<p>Atlex - At core I agree with what you write.  But how do _you_ understand the Baycol saga?  Clearly (so it seems to me), Bayer was able to run the string for a few years through spin, delay, denial, and suppressed internal studies.  Eventually, they ran out of places to hide.  But it took a few years, and it took a few people with them.</p>
<p>So, while I would not generalize to statins as a whole, there are clearly instances that support Lilli&#8217;s contention that &#8220;truth and honesty&#8221; really do make a difference, and all those studies are _not_ enough - in themselves - to keep us/docs informed.</p>
<p>They make a helluva difference if your life happens to be part of someone else&#8217;s &#8220;cost of doing business.&#8221;</p>
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		<title>By: Atlex</title>
		<link>http://www.pharmalot.com/2008/07/cholesterol-meds-for-the-youngest-children/#comment-366080</link>
		<dc:creator>Atlex</dc:creator>
		<pubDate>Wed, 09 Jul 2008 00:19:28 +0000</pubDate>
		<guid isPermaLink="false">http://www.pharmalot.com/?p=14487#comment-366080</guid>
		<description>Lilli,

There is absolutely no data to support your position.  The supposed lack of physician reporting doesn't make a difference. There are many long-term clinical and, probably more important, numerous retrospective analyses that of very large patient databases that demonstrate the general safety of statins and the significant benefits of treatment.  One might be able to argue about which patients types are appropriate for treatment, but there is no doubt about the general safety of the statins currently on the market, particularly when compared to their benefits.

Atlex</description>
		<content:encoded><![CDATA[<p>Lilli,</p>
<p>There is absolutely no data to support your position.  The supposed lack of physician reporting doesn&#8217;t make a difference. There are many long-term clinical and, probably more important, numerous retrospective analyses that of very large patient databases that demonstrate the general safety of statins and the significant benefits of treatment.  One might be able to argue about which patients types are appropriate for treatment, but there is no doubt about the general safety of the statins currently on the market, particularly when compared to their benefits.</p>
<p>Atlex</p>
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		<title>By: Lili</title>
		<link>http://www.pharmalot.com/2008/07/cholesterol-meds-for-the-youngest-children/#comment-366076</link>
		<dc:creator>Lili</dc:creator>
		<pubDate>Tue, 08 Jul 2008 23:34:49 +0000</pubDate>
		<guid isPermaLink="false">http://www.pharmalot.com/?p=14487#comment-366076</guid>
		<description>The problem with Ststins or any medication is that doctors are not monitoring the side effects.  Statins are a very dangerous medication and the pharmaceuticals could not care less if you have serious side effects. The doctors do not report the side effects and statins cause organ failure that leads to death. Rhbadomyloysis! Beacuse doctros do not report and not subject too, there  is not any evidence of how many people have Rhbadomyolysi and Peripheral Neuropathy from Statins. Clinicial Trials does not account for long term use with Statins or any other medications. We need relieable research and truth and honesty in medicine.</description>
		<content:encoded><![CDATA[<p>The problem with Ststins or any medication is that doctors are not monitoring the side effects.  Statins are a very dangerous medication and the pharmaceuticals could not care less if you have serious side effects. The doctors do not report the side effects and statins cause organ failure that leads to death. Rhbadomyloysis! Beacuse doctros do not report and not subject too, there  is not any evidence of how many people have Rhbadomyolysi and Peripheral Neuropathy from Statins. Clinicial Trials does not account for long term use with Statins or any other medications. We need relieable research and truth and honesty in medicine.</p>
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		<title>By: Doc</title>
		<link>http://www.pharmalot.com/2008/07/cholesterol-meds-for-the-youngest-children/#comment-366028</link>
		<dc:creator>Doc</dc:creator>
		<pubDate>Tue, 08 Jul 2008 14:04:12 +0000</pubDate>
		<guid isPermaLink="false">http://www.pharmalot.com/?p=14487#comment-366028</guid>
		<description>I think that the AAP has lost its mind.  These children are growing and have not yet gone through puberty.</description>
		<content:encoded><![CDATA[<p>I think that the AAP has lost its mind.  These children are growing and have not yet gone through puberty.</p>
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		<title>By: Vince</title>
		<link>http://www.pharmalot.com/2008/07/cholesterol-meds-for-the-youngest-children/#comment-366018</link>
		<dc:creator>Vince</dc:creator>
		<pubDate>Tue, 08 Jul 2008 12:44:47 +0000</pubDate>
		<guid isPermaLink="false">http://www.pharmalot.com/?p=14487#comment-366018</guid>
		<description>From a Follow up article in todays Times
http://www.nytimes.com/2008/07/08/health/08well.html?th&#38;emc=th   8-Year-Olds on Statins? A New Plan Quickly Bites Back ..........

 “To be frank, I’m embarrassed for the A.A.P. today,” said Dr. Lawrence Rosen of Hackensack University Medical Center in New Jersey, vice chairman of an academy panel on traditional and alternative medicine. He added: “Treatment with medications in the absence of any clear data? I hope they’re ready for the public backlash.”</description>
		<content:encoded><![CDATA[<p>From a Follow up article in todays Times<br />
<a href="http://www.nytimes.com/2008/07/08/health/08well.html?th&amp;emc=th" rel="nofollow">http://www.nytimes.com/2008/07/08/health/08well.html?th&amp;emc=th</a>   8-Year-Olds on Statins? A New Plan Quickly Bites Back &#8230;&#8230;&#8230;.</p>
<p> “To be frank, I’m embarrassed for the A.A.P. today,” said Dr. Lawrence Rosen of Hackensack University Medical Center in New Jersey, vice chairman of an academy panel on traditional and alternative medicine. He added: “Treatment with medications in the absence of any clear data? I hope they’re ready for the public backlash.”</p>
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		<title>By: Justice in MI</title>
		<link>http://www.pharmalot.com/2008/07/cholesterol-meds-for-the-youngest-children/#comment-365998</link>
		<dc:creator>Justice in MI</dc:creator>
		<pubDate>Tue, 08 Jul 2008 03:40:52 +0000</pubDate>
		<guid isPermaLink="false">http://www.pharmalot.com/?p=14487#comment-365998</guid>
		<description>Whatever else, interesting that this was the lead story on ABC evening news tonight and one of the featured stories on PBS.  

In general, my sense is that response to it has been a kind of Rorschach re: assumptions about the industry more generally.  Even with all the reminders that the recs are not mainly about drug tx, that (as Atlex notes) name brands would probably not play a central role, the "conspiracy narrative" arises.  

I genuinely doubt that this would have happened even twelve years ago (pre-97).  If anything, the stories would have been greeted as interesting, and potentially important, good news.

Times, indeed, have changed.</description>
		<content:encoded><![CDATA[<p>Whatever else, interesting that this was the lead story on ABC evening news tonight and one of the featured stories on PBS.  </p>
<p>In general, my sense is that response to it has been a kind of Rorschach re: assumptions about the industry more generally.  Even with all the reminders that the recs are not mainly about drug tx, that (as Atlex notes) name brands would probably not play a central role, the &#8220;conspiracy narrative&#8221; arises.  </p>
<p>I genuinely doubt that this would have happened even twelve years ago (pre-97).  If anything, the stories would have been greeted as interesting, and potentially important, good news.</p>
<p>Times, indeed, have changed.</p>
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