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	<title>Comments on: Quote Of The Day: &#8216;I&#8217;m Embarrassed For The AAP&#8217;</title>
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	<pubDate>Mon, 15 Mar 2010 23:52:24 +0000</pubDate>
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		<title>By: Justice in MI</title>
		<link>http://www.pharmalot.com/2008/07/quote-of-the-day-im-embarassed-for-the-aap/#comment-366162</link>
		<dc:creator>Justice in MI</dc:creator>
		<pubDate>Wed, 09 Jul 2008 21:45:33 +0000</pubDate>
		<guid isPermaLink="false">http://www.pharmalot.com/?p=14512#comment-366162</guid>
		<description>Thanks for the references, David.  This is not a "big issue" for me one way or other.  But it's of general interest, and happened to come up in the thread.

How about this:  You wrote, "(never mind the original nutty suggestion of statins for kids)"

I won't ask you to compare the evidence-base for pediatric statin use with, say, TM or other regular medititation for hypertension, but do I understand rightly that this is a context in mainstream medicine in which you also feel the science isn't there to back up the guidlines?  That's where this thread began.

Your thoughts apppreciated.  Thanks</description>
		<content:encoded><![CDATA[<p>Thanks for the references, David.  This is not a &#8220;big issue&#8221; for me one way or other.  But it&#8217;s of general interest, and happened to come up in the thread.</p>
<p>How about this:  You wrote, &#8220;(never mind the original nutty suggestion of statins for kids)&#8221;</p>
<p>I won&#8217;t ask you to compare the evidence-base for pediatric statin use with, say, TM or other regular medititation for hypertension, but do I understand rightly that this is a context in mainstream medicine in which you also feel the science isn&#8217;t there to back up the guidlines?  That&#8217;s where this thread began.</p>
<p>Your thoughts apppreciated.  Thanks</p>
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		<title>By: David Colquhoun</title>
		<link>http://www.pharmalot.com/2008/07/quote-of-the-day-im-embarassed-for-the-aap/#comment-366160</link>
		<dc:creator>David Colquhoun</dc:creator>
		<pubDate>Wed, 09 Jul 2008 21:31:48 +0000</pubDate>
		<guid isPermaLink="false">http://www.pharmalot.com/?p=14512#comment-366160</guid>
		<description>Well I would not say my views were 'monolithic', but rather that I'd taken the trouble to read the evidence (admittedly that's meant wasting a lot of time reading appalling papers, but at least it qualifies me to offer an opinion.)

If you want the evidence, it isn't really hard to find.  Look at the Cochrane reviews on the web. You will find only the slimmest of evidence for any sort of CAM and essentially none for the lunatic fringe like homeopathy.

Alternatively, read either of two excellent and honest books from people who have spent a long time assessing the evidence.

Trick or Treatment  by Simon Singh and Edzard Ernst, Bantam Press, 2008

Snake Oil Science, The Truth about Complementary and Alternative Medicine.  R. Barker Bausell, Oxford University Press, 2007</description>
		<content:encoded><![CDATA[<p>Well I would not say my views were &#8216;monolithic&#8217;, but rather that I&#8217;d taken the trouble to read the evidence (admittedly that&#8217;s meant wasting a lot of time reading appalling papers, but at least it qualifies me to offer an opinion.)</p>
<p>If you want the evidence, it isn&#8217;t really hard to find.  Look at the Cochrane reviews on the web. You will find only the slimmest of evidence for any sort of CAM and essentially none for the lunatic fringe like homeopathy.</p>
<p>Alternatively, read either of two excellent and honest books from people who have spent a long time assessing the evidence.</p>
<p>Trick or Treatment  by Simon Singh and Edzard Ernst, Bantam Press, 2008</p>
<p>Snake Oil Science, The Truth about Complementary and Alternative Medicine.  R. Barker Bausell, Oxford University Press, 2007</p>
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		<title>By: Justice in MI</title>
		<link>http://www.pharmalot.com/2008/07/quote-of-the-day-im-embarassed-for-the-aap/#comment-366142</link>
		<dc:creator>Justice in MI</dc:creator>
		<pubDate>Wed, 09 Jul 2008 17:20:08 +0000</pubDate>
		<guid isPermaLink="false">http://www.pharmalot.com/?p=14512#comment-366142</guid>
		<description>David wrote: "I don’t now which universe Justice in MI is living in when he says most university CAM courses use evidence."

I actually wrote no such thing.  I was referring to a year I spent as a faculty associate at our own med school.  What "most univeristy CAM courses use" is of concern to DC, but not a topic I commented upon (or could).

The fact that he needed to change the meaning of a simple sentence for the sake of his crusade probably already tells us something about his personal championing of "evidence" and "objectivity."  No evidence of either in his respose to me.

Maybe the best CAM to be recommended at this point is a long, slow look in the mirror.

For Atlex, I appreciate your note.  I am no CAM-champion in general, as my original post makes clear enough.  As I said, many of the problems "tip of the iceberg."  I was responding to Nathan's (and now DC's) monolithic denials, both of which seemed to me (for different reasons) not dealing with some of what _is_ there (to whatever degree).</description>
		<content:encoded><![CDATA[<p>David wrote: &#8220;I don’t now which universe Justice in MI is living in when he says most university CAM courses use evidence.&#8221;</p>
<p>I actually wrote no such thing.  I was referring to a year I spent as a faculty associate at our own med school.  What &#8220;most univeristy CAM courses use&#8221; is of concern to DC, but not a topic I commented upon (or could).</p>
<p>The fact that he needed to change the meaning of a simple sentence for the sake of his crusade probably already tells us something about his personal championing of &#8220;evidence&#8221; and &#8220;objectivity.&#8221;  No evidence of either in his respose to me.</p>
<p>Maybe the best CAM to be recommended at this point is a long, slow look in the mirror.</p>
<p>For Atlex, I appreciate your note.  I am no CAM-champion in general, as my original post makes clear enough.  As I said, many of the problems &#8220;tip of the iceberg.&#8221;  I was responding to Nathan&#8217;s (and now DC&#8217;s) monolithic denials, both of which seemed to me (for different reasons) not dealing with some of what _is_ there (to whatever degree).</p>
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		<title>By: David Colquhoun</title>
		<link>http://www.pharmalot.com/2008/07/quote-of-the-day-im-embarassed-for-the-aap/#comment-366138</link>
		<dc:creator>David Colquhoun</dc:creator>
		<pubDate>Wed, 09 Jul 2008 15:58:36 +0000</pubDate>
		<guid isPermaLink="false">http://www.pharmalot.com/?p=14512#comment-366138</guid>
		<description>Wrll Atlex is a bit closer.  Just look at the Cochrane reviews for heavens sake. Almost all CAM is wishful thinking or fraud.  

If this discussion (never mind the original nutty suggestion of statins for kids) is representative of the intellectual level of American Pediatrics, it makes me glad to live in Europe.</description>
		<content:encoded><![CDATA[<p>Wrll Atlex is a bit closer.  Just look at the Cochrane reviews for heavens sake. Almost all CAM is wishful thinking or fraud.  </p>
<p>If this discussion (never mind the original nutty suggestion of statins for kids) is representative of the intellectual level of American Pediatrics, it makes me glad to live in Europe.</p>
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		<title>By: Atlex</title>
		<link>http://www.pharmalot.com/2008/07/quote-of-the-day-im-embarassed-for-the-aap/#comment-366119</link>
		<dc:creator>Atlex</dc:creator>
		<pubDate>Wed, 09 Jul 2008 11:58:47 +0000</pubDate>
		<guid isPermaLink="false">http://www.pharmalot.com/?p=14512#comment-366119</guid>
		<description>JiM,

Yes, there are many RCTs of CAM; however, they are confined to a vrery limited number of conditions, diseases, and maladies.  However, many, if not most, of the "claims" associated with these treatments have no RCTs to back them up.  That doesn't mean they don't work, but it doesn't mean they do work either.

Atlex</description>
		<content:encoded><![CDATA[<p>JiM,</p>
<p>Yes, there are many RCTs of CAM; however, they are confined to a vrery limited number of conditions, diseases, and maladies.  However, many, if not most, of the &#8220;claims&#8221; associated with these treatments have no RCTs to back them up.  That doesn&#8217;t mean they don&#8217;t work, but it doesn&#8217;t mean they do work either.</p>
<p>Atlex</p>
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		<title>By: Justice in MI</title>
		<link>http://www.pharmalot.com/2008/07/quote-of-the-day-im-embarassed-for-the-aap/#comment-366095</link>
		<dc:creator>Justice in MI</dc:creator>
		<pubDate>Wed, 09 Jul 2008 02:13:01 +0000</pubDate>
		<guid isPermaLink="false">http://www.pharmalot.com/?p=14512#comment-366095</guid>
		<description>For David C - Well, we folks who live here call it the "milky way," but that's probably not what they call it in, say, Andromeda.  

I don't have the time (or, frankly, the inclination) to list some of the most interesting double-blinded RCTs of CAM therapies.  But if you tell me they don't exist...well, give my best to all the folks in Andromeda.  

Kirk out.</description>
		<content:encoded><![CDATA[<p>For David C - Well, we folks who live here call it the &#8220;milky way,&#8221; but that&#8217;s probably not what they call it in, say, Andromeda.  </p>
<p>I don&#8217;t have the time (or, frankly, the inclination) to list some of the most interesting double-blinded RCTs of CAM therapies.  But if you tell me they don&#8217;t exist&#8230;well, give my best to all the folks in Andromeda.  </p>
<p>Kirk out.</p>
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		<title>By: Doc</title>
		<link>http://www.pharmalot.com/2008/07/quote-of-the-day-im-embarassed-for-the-aap/#comment-366081</link>
		<dc:creator>Doc</dc:creator>
		<pubDate>Wed, 09 Jul 2008 00:20:53 +0000</pubDate>
		<guid isPermaLink="false">http://www.pharmalot.com/?p=14512#comment-366081</guid>
		<description>PR Hack,
Virtually no drug given chronically, except maybe warfarin and digoxin have a 'lifetime' of data behind them. Most studies are done for specific time frames with enough calculated endpoints to see if stat sig is reached. You are greatly mistaken going that route. Should childern be given these drugs? That is a different question, however in adults giving chronic therapy for hypertension, high cholesterol, hyperglycemia, etc based on 2-5 year studies is valid. Try stopping those therapies at 3-5 years like the studies and see what happens.</description>
		<content:encoded><![CDATA[<p>PR Hack,<br />
Virtually no drug given chronically, except maybe warfarin and digoxin have a &#8216;lifetime&#8217; of data behind them. Most studies are done for specific time frames with enough calculated endpoints to see if stat sig is reached. You are greatly mistaken going that route. Should childern be given these drugs? That is a different question, however in adults giving chronic therapy for hypertension, high cholesterol, hyperglycemia, etc based on 2-5 year studies is valid. Try stopping those therapies at 3-5 years like the studies and see what happens.</p>
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		<title>By: pharma pr hack</title>
		<link>http://www.pharmalot.com/2008/07/quote-of-the-day-im-embarassed-for-the-aap/#comment-366075</link>
		<dc:creator>pharma pr hack</dc:creator>
		<pubDate>Tue, 08 Jul 2008 22:58:18 +0000</pubDate>
		<guid isPermaLink="false">http://www.pharmalot.com/?p=14512#comment-366075</guid>
		<description>This is  from WebMD. You will note that statins may be great for people with heart and vascular disease. But in the US pharma is pushing them like f***ing candy. These are serious drugs with serious side effects. 

They work well in individuals with these diseases but why would you take something preventatively that may or may not help something you may or may not get down the road but definitely will give you significant side effects. TO CHILDREN. 

I don't know if you have ever looked around but there is already a really long waiting list for organs in this country and a pitiful amount given each year- less than a thousand;  but most statins can either a) raise liver enzymes or b) cause kidney damage. Where are all these organs going to come from to replace the ones that are going to be shot from overmedicating kids from cardiac possibilities not even probabilities? 

These drugs weren't tested or made to be long term lifetime drugs. None have even been around for all of my lifetime- are you really willing to risk your child to guard against the possibility of something that may or may not happen? With those kinds of side effects?


June 6, 2007 -- The benefits of taking cholesterol-lowering statin drugs far outweigh the potential risks for the vast majority of patients with heart and vascular disease, a new review of the research suggests.

Longtime statin researcher Jane Armitage, MD, of the University of Oxford, found the incidence of serious side effects to be very rare in patients taking standard doses of the drugs, although the risks rose with higher doses.</description>
		<content:encoded><![CDATA[<p>This is  from WebMD. You will note that statins may be great for people with heart and vascular disease. But in the US pharma is pushing them like f***ing candy. These are serious drugs with serious side effects. </p>
<p>They work well in individuals with these diseases but why would you take something preventatively that may or may not help something you may or may not get down the road but definitely will give you significant side effects. TO CHILDREN. </p>
<p>I don&#8217;t know if you have ever looked around but there is already a really long waiting list for organs in this country and a pitiful amount given each year- less than a thousand;  but most statins can either a) raise liver enzymes or b) cause kidney damage. Where are all these organs going to come from to replace the ones that are going to be shot from overmedicating kids from cardiac possibilities not even probabilities? </p>
<p>These drugs weren&#8217;t tested or made to be long term lifetime drugs. None have even been around for all of my lifetime- are you really willing to risk your child to guard against the possibility of something that may or may not happen? With those kinds of side effects?</p>
<p>June 6, 2007 &#8212; The benefits of taking cholesterol-lowering statin drugs far outweigh the potential risks for the vast majority of patients with heart and vascular disease, a new review of the research suggests.</p>
<p>Longtime statin researcher Jane Armitage, MD, of the University of Oxford, found the incidence of serious side effects to be very rare in patients taking standard doses of the drugs, although the risks rose with higher doses.</p>
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		<title>By: David Colquhoun</title>
		<link>http://www.pharmalot.com/2008/07/quote-of-the-day-im-embarassed-for-the-aap/#comment-366073</link>
		<dc:creator>David Colquhoun</dc:creator>
		<pubDate>Tue, 08 Jul 2008 21:38:37 +0000</pubDate>
		<guid isPermaLink="false">http://www.pharmalot.com/?p=14512#comment-366073</guid>
		<description>I don't now which universe Justice in MI is living in when he says most university CAM courses use evidence.

Well perhaps Yale's "more fluid concept of evidence" as documented in Integrative baloney @ Yale, http://dcscience.net/?p=231
The spoof video on YouTunbe of Yale's contribution to endarkenment thinking has had a lot mote views that the originals, so perhaps there is hope yet for reason.

The fact is that most CAM activities in US medical schools don't give a damn about evidence, as long as the bucks flow in from NCCAM and Bravewell.
They are making a laughing stock of US medicine, which is being set back to the days of make-believe that prevailed before the Flexner report (1810), or before the age of enlightenment itself.</description>
		<content:encoded><![CDATA[<p>I don&#8217;t now which universe Justice in MI is living in when he says most university CAM courses use evidence.</p>
<p>Well perhaps Yale&#8217;s &#8220;more fluid concept of evidence&#8221; as documented in Integrative baloney @ Yale, <a href="http://dcscience.net/?p=231" rel="nofollow">http://dcscience.net/?p=231</a><br />
The spoof video on YouTunbe of Yale&#8217;s contribution to endarkenment thinking has had a lot mote views that the originals, so perhaps there is hope yet for reason.</p>
<p>The fact is that most CAM activities in US medical schools don&#8217;t give a damn about evidence, as long as the bucks flow in from NCCAM and Bravewell.<br />
They are making a laughing stock of US medicine, which is being set back to the days of make-believe that prevailed before the Flexner report (1810), or before the age of enlightenment itself.</p>
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		<title>By: Justice in MI</title>
		<link>http://www.pharmalot.com/2008/07/quote-of-the-day-im-embarassed-for-the-aap/#comment-366067</link>
		<dc:creator>Justice in MI</dc:creator>
		<pubDate>Tue, 08 Jul 2008 20:48:12 +0000</pubDate>
		<guid isPermaLink="false">http://www.pharmalot.com/?p=14512#comment-366067</guid>
		<description>Nathan - I agree that, overall, there has not been the same degree of study (for the obvious reasons of funding, regulatory requirements, the fact of being "alternative", etc.)

But I was surprised at the number of RCTs with placebo there actually are of many CAM modalities.  (I spent a year at our med school in a program about them.)  Clearly, that is easier to do for some than others, although I'm sure you heard about the "fake acupuncture" studies and others.  

What personally concerns me the most are the herbs and other supplements, and how little we know about adverses, interactions, etc., not to mention the amount of adulteration and misbranding.  Happened to run across an "all natural", guaranteed cholesterol product the other day that was full of red yeast rice, etc.  And yet it advertised itself as "entirely safe," "statin-free," so "side-effects," etc..

Tip of iceberg.</description>
		<content:encoded><![CDATA[<p>Nathan - I agree that, overall, there has not been the same degree of study (for the obvious reasons of funding, regulatory requirements, the fact of being &#8220;alternative&#8221;, etc.)</p>
<p>But I was surprised at the number of RCTs with placebo there actually are of many CAM modalities.  (I spent a year at our med school in a program about them.)  Clearly, that is easier to do for some than others, although I&#8217;m sure you heard about the &#8220;fake acupuncture&#8221; studies and others.  </p>
<p>What personally concerns me the most are the herbs and other supplements, and how little we know about adverses, interactions, etc., not to mention the amount of adulteration and misbranding.  Happened to run across an &#8220;all natural&#8221;, guaranteed cholesterol product the other day that was full of red yeast rice, etc.  And yet it advertised itself as &#8220;entirely safe,&#8221; &#8220;statin-free,&#8221; so &#8220;side-effects,&#8221; etc..</p>
<p>Tip of iceberg.</p>
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