Comments on: Upcoming Crestor Study May Be A ‘Game Changer’ http://www.pharmalot.com/2008/10/upcoming-crestor-study-may-be-a-game-changer/ News, Comment and Conversation Mon, 22 Mar 2010 14:06:24 +0000 http://wordpress.org/?v=2.6.2 By: Cherrie weaver http://www.pharmalot.com/2008/10/upcoming-crestor-study-may-be-a-game-changer/#comment-422559 Cherrie weaver Thu, 27 Aug 2009 02:58:00 +0000 http://www.pharmalot.com/?p=17106#comment-422559 Did you have any side effects from Simvastatin? I have been prescribed this but have a fear of taking it because of all the side effects I have read about. Did you have any side effects from Simvastatin? I have been prescribed this but have a fear of taking it because of all the side effects I have read about.

]]> By: Lily http://www.pharmalot.com/2008/10/upcoming-crestor-study-may-be-a-game-changer/#comment-381335 Lily Thu, 13 Nov 2008 21:30:08 +0000 http://www.pharmalot.com/?p=17106#comment-381335 I looked up the price for Crestor 10 mg on drugstore.com. It was $111 for 30 tablets. With my RxDrugCard I can get 30 Simvastatin 10 mg for $8. If it turns out that one statin is as good as another, I'm going for the generic!! I looked up the price for Crestor 10 mg on drugstore.com. It was $111 for 30 tablets. With my RxDrugCard I can get 30 Simvastatin 10 mg for $8. If it turns out that one statin is as good as another, I’m going for the generic!!

]]> By: Marilyn Mann http://www.pharmalot.com/2008/10/upcoming-crestor-study-may-be-a-game-changer/#comment-379980 Marilyn Mann Sat, 01 Nov 2008 18:22:40 +0000 http://www.pharmalot.com/?p=17106#comment-379980 Here's the link to the study on genetically elevated CRP: http://content.nejm.org/cgi/content/short/359/18/1897 Here’s the link to the study on genetically elevated CRP:

http://content.nejm.org/cgi/content/short/359/18/1897

]]> By: Marilyn Mann http://www.pharmalot.com/2008/10/upcoming-crestor-study-may-be-a-game-changer/#comment-379970 Marilyn Mann Sat, 01 Nov 2008 16:21:13 +0000 http://www.pharmalot.com/?p=17106#comment-379970 I believe the people in the trial had an LDL level of 130 or below. Whether that is a "low" level would depend on how you defined "low." Because statins lower both LDL and CRP, it is impossible to tell how much of the benefit is coming from lowering CRP, how much from lowering LDL, and how much from other effects unrelated to LDL and CRP. Whether CRP causes heart disease, or is simply a marker of increased risk, is controversial. A study was just published that showed that people with genetic variants that cause increased CRP throughout their lifetime had no increased risk of heart disease. This is in contrast to people with familial hypercholesterolemia (i.e., increased LDL due to a genetic mutation), who do have increased risk. Nonetheless, I agree that if someone has elevated CRP but "normal" LDL, they could consider taking a statin, especially if they have other risk factors. Everyone has to weigh their own personal risk and make their own choice. At least, that's my philosophy. I believe the people in the trial had an LDL level of 130 or below. Whether that is a “low” level would depend on how you defined “low.” Because statins lower both LDL and CRP, it is impossible to tell how much of the benefit is coming from lowering CRP, how much from lowering LDL, and how much from other effects unrelated to LDL and CRP.

Whether CRP causes heart disease, or is simply a marker of increased risk, is controversial. A study was just published that showed that people with genetic variants that cause increased CRP throughout their lifetime had no increased risk of heart disease. This is in contrast to people with familial hypercholesterolemia (i.e., increased LDL due to a genetic mutation), who do have increased risk.

Nonetheless, I agree that if someone has elevated CRP but “normal” LDL, they could consider taking a statin, especially if they have other risk factors. Everyone has to weigh their own personal risk and make their own choice. At least, that’s my philosophy.

]]> By: Georgie http://www.pharmalot.com/2008/10/upcoming-crestor-study-may-be-a-game-changer/#comment-379811 Georgie Fri, 31 Oct 2008 13:13:01 +0000 http://www.pharmalot.com/?p=17106#comment-379811 Stash of what? Old jazz mags? Stash of what? Old jazz mags?

]]> By: Lisa Van S http://www.pharmalot.com/2008/10/upcoming-crestor-study-may-be-a-game-changer/#comment-379757 Lisa Van S Fri, 31 Oct 2008 04:02:55 +0000 http://www.pharmalot.com/?p=17106#comment-379757 Ed, How funny is this!! I recently purchased a home from a Crestor Drug Rep. The individual left behind quit a few goodies; Doc Pads, Pens, and his own personal stash!!! More revealing was the Info to Docs, They are Targeting Women. Ed,

How funny is this!! I recently purchased a home from a Crestor Drug Rep. The individual left behind quit a few goodies; Doc Pads, Pens, and his own personal stash!!! More revealing was the Info to Docs, They are Targeting Women.

]]>