Comments on: Biederman Denies Conflict Of Interest Charges http://www.pharmalot.com/2008/12/biederman-denies-conflict-of-interest-charges/ News, Comment and Conversation Sun, 21 Mar 2010 04:54:17 +0000 http://wordpress.org/?v=2.6.2 By: truthman30 http://www.pharmalot.com/2008/12/biederman-denies-conflict-of-interest-charges/#comment-384109 truthman30 Tue, 09 Dec 2008 17:18:01 +0000 http://www.pharmalot.com/?p=18360#comment-384109 Psychiatrists are in denial about a lot of things.. Because psychiatrists are the most deluded human beings on the face of the planet,.. Psychiatrists are in denial about a lot of things..
Because psychiatrists are the most deluded human beings on the face of the planet,..

]]> By: Texan http://www.pharmalot.com/2008/12/biederman-denies-conflict-of-interest-charges/#comment-384092 Texan Tue, 09 Dec 2008 14:36:08 +0000 http://www.pharmalot.com/?p=18360#comment-384092 I'm with you on this, Justice -- I smell a red herring. I’m with you on this, Justice — I smell a red herring.

]]> By: David M. http://www.pharmalot.com/2008/12/biederman-denies-conflict-of-interest-charges/#comment-384088 David M. Tue, 09 Dec 2008 12:57:29 +0000 http://www.pharmalot.com/?p=18360#comment-384088 Well, Schatzberg at Stanford did nothing wrong. And Goodwin did nothing wrong. Are we surprised to hear that Biederman thinks that he did nothing wrong? When do we hear Nemeroff explain that he "did nothing wrong?" Well, Schatzberg at Stanford did nothing wrong. And Goodwin did nothing wrong. Are we surprised to hear that Biederman thinks that he did nothing wrong?

When do we hear Nemeroff explain that he “did nothing wrong?”

]]> By: Jane http://www.pharmalot.com/2008/12/biederman-denies-conflict-of-interest-charges/#comment-384067 Jane Tue, 09 Dec 2008 00:06:55 +0000 http://www.pharmalot.com/?p=18360#comment-384067 Breiderman is nothing but a baby killer! Breiderman is nothing but a baby killer!

]]> By: Justice in Michigan http://www.pharmalot.com/2008/12/biederman-denies-conflict-of-interest-charges/#comment-384062 Justice in Michigan Mon, 08 Dec 2008 22:38:38 +0000 http://www.pharmalot.com/?p=18360#comment-384062 Based on what I'm reading here, Dr. B. does not respond at all to the failure to disclose $1.6 million issue. Based on what I’m reading here, Dr. B. does not respond at all to the failure to disclose $1.6 million issue.

]]> By: Salmon http://www.pharmalot.com/2008/12/biederman-denies-conflict-of-interest-charges/#comment-384058 Salmon Mon, 08 Dec 2008 21:56:31 +0000 http://www.pharmalot.com/?p=18360#comment-384058 new information out in Psychiatric Times in the last few minutes on the safety of Ziprasidone in adolescents 10 - 17. 5% of kids on Ziprasidone had symptoms of cardiac toxicity. However there was also a lot of sedation and dizziness which could also be symptoms. This was a 26 week study but we don't know if symptoms occurred early (i.e. in kids who were genetically predisposed) or later. Plus we don't know what is the distribution of kids in the study and their dosages, i.e. was it mainly 16 and 17 year olds with only a one 10 year old who would have a proportionately higher dose (unless the 10 year old was 5'8" and weighed 170 lbs.) and yes that does happen intentionally. There was also a safety study of Zyprexa and lithium in kids but it was ONLY 12 kids. Personally I think there is likely an increased cardiac toxicity when certain antipsychotics are given with lithium, and this study will only provide a false sense of reassurance. See the following link. http://www.psychiatrictimes.com/display/article/10168/1357787 Notice the info on QTcF prolongation. This is being used as a biomarker for submission to FDA but it's probably be misleading to a degree. Salmon new information out in Psychiatric Times in the last few minutes on the safety of Ziprasidone in adolescents 10 - 17. 5% of kids on Ziprasidone had symptoms of cardiac toxicity. However there was also a lot of sedation and dizziness which could also be symptoms.

This was a 26 week study but we don’t know if symptoms occurred early (i.e. in kids who were genetically predisposed) or later. Plus we don’t know what is the distribution of kids in the study and their dosages, i.e. was it mainly 16 and 17 year olds with only a one 10 year old who would have a proportionately higher dose (unless the 10 year old was 5′8″ and weighed 170 lbs.) and yes that does happen intentionally.

There was also a safety study of Zyprexa and lithium in kids but it was ONLY 12 kids. Personally I think there is likely an increased cardiac toxicity when certain antipsychotics are given with lithium, and this study will only provide a false sense of reassurance.

See the following link.

http://www.psychiatrictimes.com/display/article/10168/1357787

Notice the info on QTcF prolongation. This is being used as a biomarker for submission to FDA but it’s probably be misleading to a degree.

Salmon

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