Comments on: Eyes Wide Open? A Pill To Fight Jet Lag http://www.pharmalot.com/2008/12/eyes-wide-open-a-pill-to-fight-jet-lag/ News, Comment and Conversation Fri, 10 Feb 2012 17:55:24 +0000 http://wordpress.org/?v=2.6.2 By: wizened http://www.pharmalot.com/2008/12/eyes-wide-open-a-pill-to-fight-jet-lag/#comment-383534 wizened Wed, 03 Dec 2008 02:16:51 +0000 http://www.pharmalot.com/?p=18145#comment-383534 If this company is serious about a jet lag indication, they will not be able to get away with a sleep lab simulation study as a pivotal study. I know of at least one large pharma company that is doing a phase IV study for a jet lag indication wherein they a chartering a planeload of study subjects to fly from US to Europe to measure true jet lag. This is not a joke. I doubt that this small company would be able to fund this study on its own. Besides, with Ambien gone generic, such a study would not be cost effective. If this company is serious about a jet lag indication, they will not be able to get away with a sleep lab simulation study as a pivotal study. I know of at least one large pharma company that is doing a phase IV study for a jet lag indication wherein they a chartering a planeload of study subjects to fly from US to Europe to measure true jet lag. This is not a joke. I doubt that this small company would be able to fund this study on its own. Besides, with Ambien gone generic, such a study would not be cost effective.

]]> By: Van http://www.pharmalot.com/2008/12/eyes-wide-open-a-pill-to-fight-jet-lag/#comment-383499 Van Tue, 02 Dec 2008 18:51:36 +0000 http://www.pharmalot.com/?p=18145#comment-383499 Hi Ed, From reading the article (and one other) I can't tell is this simply an amped up version of Melatonin? Not that Melatonin has ever helped me with insomnia, but this really sounds like a marketing ploy by Vanda Pharmaceuticals... Best, Van <a href="http://vansantos.com" rel="nofollow">http://vansantos.com</a> Hi Ed,

From reading the article (and one other) I can’t tell is this simply an amped up version of Melatonin?

Not that Melatonin has ever helped me with insomnia, but this really sounds like a marketing ploy by Vanda Pharmaceuticals…

Best,
Van
http://vansantos.com

]]> By: pharmavet http://www.pharmalot.com/2008/12/eyes-wide-open-a-pill-to-fight-jet-lag/#comment-383493 pharmavet Tue, 02 Dec 2008 18:12:25 +0000 http://www.pharmalot.com/?p=18145#comment-383493 Any new treatment for jet lag should avoid the amnestic effects of Ambien. I took Ambien once during a flight to a business meeting from New York to Paris. I had the unpleasant experience of not being able to remember anything about how I got to Paris. There are published non-pharmacological methods to prevent or minimize jet lag. If approved this pill carry a label that should be used when non drug measures fail, such as diet and exercise be tried before antidiabetic drugs. Any new treatment for jet lag should avoid the amnestic effects of Ambien. I took Ambien once during a flight to a business meeting from New York to Paris. I had the unpleasant experience of not being able to remember anything about how I got to Paris. There are published non-pharmacological methods to prevent or minimize jet lag. If approved this pill carry a label that should be used when non drug measures fail, such as diet and exercise be tried before antidiabetic drugs.

]]> By: Ed Silverman http://www.pharmalot.com/2008/12/eyes-wide-open-a-pill-to-fight-jet-lag/#comment-383468 Ed Silverman Tue, 02 Dec 2008 15:41:00 +0000 http://www.pharmalot.com/?p=18145#comment-383468 Hi Mike, Thanks for the note. Much appreciated. I've just inserted the additional fact. Cheers ed Hi Mike,

Thanks for the note. Much appreciated. I’ve just inserted the additional fact.

Cheers
ed

]]> By: Mike M http://www.pharmalot.com/2008/12/eyes-wide-open-a-pill-to-fight-jet-lag/#comment-383464 Mike M Tue, 02 Dec 2008 15:13:48 +0000 http://www.pharmalot.com/?p=18145#comment-383464 Ed, This story seems incomplete without mentioning that tasimelteon is nothing more than a "me too" version of the commercially available ramelteon. At the very least it would be appropriate to have a clarifying statement that this compound is not even close to a novel drug, and perhaps that ramelteon, as well as the dietary supplement melatonin have similar caliber data for helping with jet lag. Ed,

This story seems incomplete without mentioning that tasimelteon is nothing more than a “me too” version of the commercially available ramelteon. At the very least it would be appropriate to have a clarifying statement that this compound is not even close to a novel drug, and perhaps that ramelteon, as well as the dietary supplement melatonin have similar caliber data for helping with jet lag.

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