<?xml version="1.0" encoding="UTF-8"?><rss version="2.0"
	xmlns:content="http://purl.org/rss/1.0/modules/content/"
	xmlns:dc="http://purl.org/dc/elements/1.1/"
	xmlns:atom="http://www.w3.org/2005/Atom"
	>
<channel>
	<title>Comments on: Can Cholesterol Pills Really Prevent Flu Deaths?</title>
	<atom:link href="http://www.pharmalot.com/2009/10/can-cholesterol-pills-really-prevent-flu-deaths/feed" rel="self" type="application/rss+xml" />
	<link>http://www.pharmalot.com/2009/10/can-cholesterol-pills-really-prevent-flu-deaths/</link>
	<description>News, Comment and Conversation</description>
	<pubDate>Fri, 10 Feb 2012 20:57:22 +0000</pubDate>
	<generator>http://wordpress.org/?v=2.6.2</generator>
		<item>
		<title>By: vince</title>
		<link>http://www.pharmalot.com/2009/10/can-cholesterol-pills-really-prevent-flu-deaths/#comment-443138</link>
		<dc:creator>vince</dc:creator>
		<pubDate>Mon, 02 Nov 2009 16:21:24 +0000</pubDate>
		<guid isPermaLink="false">http://www.pharmalot.com/?p=19449#comment-443138</guid>
		<description>Maybe this one.    Cardiovasc Drugs Ther. Aug 2009 ..."Increased levels of 25 hydroxyvitamin d and 1,25-dihydroxyvitamin D after rosuvastatin treatment: a novel pleiotropic effect of statins?".......There was a significant increase in 25-hydroxyvitamin D, from mean 14.0 (range 3.7- 67) to mean 36.3 (range 3.8 -117) ng/ml (p &#60; 0.001),.....CONCLUSION: This study has shown an effect of rosuvastatin on vitamin D metabolism, with an increase in both 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D. This may be an important pleiotropic effect whereby rosuvastatin reduces mortality in patients with coronary artery disease....

   And vitamin d has been linked to numerous health benefits including enhanced immune response. Statin the water. ? Or a short walk in the sun?</description>
		<content:encoded><![CDATA[<p>Maybe this one.    Cardiovasc Drugs Ther. Aug 2009 &#8230;&#8221;Increased levels of 25 hydroxyvitamin d and 1,25-dihydroxyvitamin D after rosuvastatin treatment: a novel pleiotropic effect of statins?&#8221;&#8230;&#8230;.There was a significant increase in 25-hydroxyvitamin D, from mean 14.0 (range 3.7- 67) to mean 36.3 (range 3.8 -117) ng/ml (p &lt; 0.001),&#8230;..CONCLUSION: This study has shown an effect of rosuvastatin on vitamin D metabolism, with an increase in both 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D. This may be an important pleiotropic effect whereby rosuvastatin reduces mortality in patients with coronary artery disease&#8230;.</p>
<p>   And vitamin d has been linked to numerous health benefits including enhanced immune response. Statin the water. ? Or a short walk in the sun?</p>
]]></content:encoded>
	</item>
	<item>
		<title>By: DoctorSH</title>
		<link>http://www.pharmalot.com/2009/10/can-cholesterol-pills-really-prevent-flu-deaths/#comment-443082</link>
		<dc:creator>DoctorSH</dc:creator>
		<pubDate>Sun, 01 Nov 2009 13:56:27 +0000</pubDate>
		<guid isPermaLink="false">http://www.pharmalot.com/?p=19449#comment-443082</guid>
		<description>I forget where I saw it, but one of the possible mechanisms of statins is that it makes vitamin-D more active, which has also been shown to decrease risk of influenza.</description>
		<content:encoded><![CDATA[<p>I forget where I saw it, but one of the possible mechanisms of statins is that it makes vitamin-D more active, which has also been shown to decrease risk of influenza.</p>
]]></content:encoded>
	</item>
	<item>
		<title>By: World Vitamins Online</title>
		<link>http://www.pharmalot.com/2009/10/can-cholesterol-pills-really-prevent-flu-deaths/#comment-442836</link>
		<dc:creator>World Vitamins Online</dc:creator>
		<pubDate>Sat, 31 Oct 2009 14:31:38 +0000</pubDate>
		<guid isPermaLink="false">http://www.pharmalot.com/?p=19449#comment-442836</guid>
		<description>Before people run to their doctors to get statin drugs they need to question who paid for this study. Only then can they determine if this is real or yet another attempt by corrupt drug companies to increase profits. It seems questionable to me this comes out while we are watching news stories of vaccine shortages.</description>
		<content:encoded><![CDATA[<p>Before people run to their doctors to get statin drugs they need to question who paid for this study. Only then can they determine if this is real or yet another attempt by corrupt drug companies to increase profits. It seems questionable to me this comes out while we are watching news stories of vaccine shortages.</p>
]]></content:encoded>
	</item>
	<item>
		<title>By: Patrick T. Prendergast</title>
		<link>http://www.pharmalot.com/2009/10/can-cholesterol-pills-really-prevent-flu-deaths/#comment-442814</link>
		<dc:creator>Patrick T. Prendergast</dc:creator>
		<pubDate>Sat, 31 Oct 2009 12:29:06 +0000</pubDate>
		<guid isPermaLink="false">http://www.pharmalot.com/?p=19449#comment-442814</guid>
		<description>European Journal of Pharmaceutical Sciences July 2009
Journal homepage: www.elsevier.com/locate/ejps

Evaluation of the efficacy and safety of a statin/caffeine combination against  H5N1, H3N2 and H1N1 virus infection in BALB/c mice.

a b s t r a c t

The development of novel antiviral drugs is necessary for the prevention and treatment of a potential avian influenza pandemic. The aim of this study was to evaluate the efficacy and safety of a novel statin/caffeine combination against H5N1,H3N2 and H1N1virus infection in a murine model. In H5N1-, H3N2- and H1N1- infected BALB/c mice, 50g statin/200g caffeine effectively ameliorated lung damage and inhibited viral replication and was at least as effective as oseltamivir(Tamiflu) and Ribavirin. The statin/caffeine combination also appeared to be more effective when administered preventatively rather than as treatment. These findings provide justification for further research into this novel antiviral formulation.

Authors:   Zeyu Liua,c, Zhongmin Guob, GuolingWangc, Dingmei Zhanga, Hongxuan Hed, Guowei Li a,
Yuge Liua, Denise Higginse, AoiffeWalshe, Leo Shanahan-Prendergast e, Jiahai Lua,∗
a School of Public Health, State Ministry of Education Key Laboratory of Tropical Diseases Control Research, Sun Yat-sen University,
74# Zhongshan 2 Road, Guangzhou 510080, PR China
b Experiment Animal Center, Sun Yat-sen University, Guangzhou 510080, PR China
c Haizhu Center for Disease Control and Prevention, Guangzhou 510288, PR China
d National Research Centre for Wildlife Borne Disease Institute of Zoology, Chinese Academy of Sciences, Beijing 100080, PR China
e Canopus BioPharma, 11825 Ventura Blvd., Los Angeles, CA 91604, USA</description>
		<content:encoded><![CDATA[<p>European Journal of Pharmaceutical Sciences July 2009<br />
Journal homepage: <a href="http://www.elsevier.com/locate/ejps" rel="nofollow">http://www.elsevier.com/locate/ejps</a></p>
<p>Evaluation of the efficacy and safety of a statin/caffeine combination against  H5N1, H3N2 and H1N1 virus infection in BALB/c mice.</p>
<p>a b s t r a c t</p>
<p>The development of novel antiviral drugs is necessary for the prevention and treatment of a potential avian influenza pandemic. The aim of this study was to evaluate the efficacy and safety of a novel statin/caffeine combination against H5N1,H3N2 and H1N1virus infection in a murine model. In H5N1-, H3N2- and H1N1- infected BALB/c mice, 50g statin/200g caffeine effectively ameliorated lung damage and inhibited viral replication and was at least as effective as oseltamivir(Tamiflu) and Ribavirin. The statin/caffeine combination also appeared to be more effective when administered preventatively rather than as treatment. These findings provide justification for further research into this novel antiviral formulation.</p>
<p>Authors:   Zeyu Liua,c, Zhongmin Guob, GuolingWangc, Dingmei Zhanga, Hongxuan Hed, Guowei Li a,<br />
Yuge Liua, Denise Higginse, AoiffeWalshe, Leo Shanahan-Prendergast e, Jiahai Lua,∗<br />
a School of Public Health, State Ministry of Education Key Laboratory of Tropical Diseases Control Research, Sun Yat-sen University,<br />
74# Zhongshan 2 Road, Guangzhou 510080, PR China<br />
b Experiment Animal Center, Sun Yat-sen University, Guangzhou 510080, PR China<br />
c Haizhu Center for Disease Control and Prevention, Guangzhou 510288, PR China<br />
d National Research Centre for Wildlife Borne Disease Institute of Zoology, Chinese Academy of Sciences, Beijing 100080, PR China<br />
e Canopus BioPharma, 11825 Ventura Blvd., Los Angeles, CA 91604, USA</p>
]]></content:encoded>
	</item>
	<item>
		<title>By: Flow Max</title>
		<link>http://www.pharmalot.com/2009/10/can-cholesterol-pills-really-prevent-flu-deaths/#comment-442705</link>
		<dc:creator>Flow Max</dc:creator>
		<pubDate>Fri, 30 Oct 2009 23:56:10 +0000</pubDate>
		<guid isPermaLink="false">http://www.pharmalot.com/?p=19449#comment-442705</guid>
		<description>Personally, I have been able to walk on water ever since starting a statin.

Unfortunately, it's my own water.</description>
		<content:encoded><![CDATA[<p>Personally, I have been able to walk on water ever since starting a statin.</p>
<p>Unfortunately, it&#8217;s my own water.</p>
]]></content:encoded>
	</item>
	<item>
		<title>By: Paul</title>
		<link>http://www.pharmalot.com/2009/10/can-cholesterol-pills-really-prevent-flu-deaths/#comment-442666</link>
		<dc:creator>Paul</dc:creator>
		<pubDate>Fri, 30 Oct 2009 20:47:20 +0000</pubDate>
		<guid isPermaLink="false">http://www.pharmalot.com/?p=19449#comment-442666</guid>
		<description>I love the chutzpah of some people on this site.

One day people go nuts in support of products with absolutely no evidence (see Avastin vs. Lucentis debate) and the next day people dismiss when there is some evidence that may sell more of some products.

I agree that this is retrospective analysis, but seems rigourous enough (controlled for other variables) to make it intriguing.  Also, there's lots of other basic science evidence supporting anti-inflammatory properties of statins.  This is how science often happens....</description>
		<content:encoded><![CDATA[<p>I love the chutzpah of some people on this site.</p>
<p>One day people go nuts in support of products with absolutely no evidence (see Avastin vs. Lucentis debate) and the next day people dismiss when there is some evidence that may sell more of some products.</p>
<p>I agree that this is retrospective analysis, but seems rigourous enough (controlled for other variables) to make it intriguing.  Also, there&#8217;s lots of other basic science evidence supporting anti-inflammatory properties of statins.  This is how science often happens&#8230;.</p>
]]></content:encoded>
	</item>
	<item>
		<title>By: Lilly K</title>
		<link>http://www.pharmalot.com/2009/10/can-cholesterol-pills-really-prevent-flu-deaths/#comment-442657</link>
		<dc:creator>Lilly K</dc:creator>
		<pubDate>Fri, 30 Oct 2009 20:04:53 +0000</pubDate>
		<guid isPermaLink="false">http://www.pharmalot.com/?p=19449#comment-442657</guid>
		<description>So what's new? The silent killer of the elderly has now become "THE MIRACLE WONDER CURE ALL PILL!"
It is the silient killer because doctors are not reporting the many serious dangerous  adverse side effects that statins have caused---in fact many deaths from statins are not reported-and instead doctors  are pushing statins on everyone.  
All research studies should be required to diclose the researchers financiaL DISCLOSURES and the author's affiliations.</description>
		<content:encoded><![CDATA[<p>So what&#8217;s new? The silent killer of the elderly has now become &#8220;THE MIRACLE WONDER CURE ALL PILL!&#8221;<br />
It is the silient killer because doctors are not reporting the many serious dangerous  adverse side effects that statins have caused&#8212;in fact many deaths from statins are not reported-and instead doctors  are pushing statins on everyone.<br />
All research studies should be required to diclose the researchers financiaL DISCLOSURES and the author&#8217;s affiliations.</p>
]]></content:encoded>
	</item>
	<item>
		<title>By: Zeke</title>
		<link>http://www.pharmalot.com/2009/10/can-cholesterol-pills-really-prevent-flu-deaths/#comment-442646</link>
		<dc:creator>Zeke</dc:creator>
		<pubDate>Fri, 30 Oct 2009 19:05:33 +0000</pubDate>
		<guid isPermaLink="false">http://www.pharmalot.com/?p=19449#comment-442646</guid>
		<description>And statins will also cure hallitosis, make it less likely to get ingrown toenails, treat multiple myeloma, and solve global warming as well.</description>
		<content:encoded><![CDATA[<p>And statins will also cure hallitosis, make it less likely to get ingrown toenails, treat multiple myeloma, and solve global warming as well.</p>
]]></content:encoded>
	</item>
	<item>
		<title>By: riv</title>
		<link>http://www.pharmalot.com/2009/10/can-cholesterol-pills-really-prevent-flu-deaths/#comment-442634</link>
		<dc:creator>riv</dc:creator>
		<pubDate>Fri, 30 Oct 2009 17:26:08 +0000</pubDate>
		<guid isPermaLink="false">http://www.pharmalot.com/?p=19449#comment-442634</guid>
		<description>Thanks for sharing this information?! 

Ye gads what a perfect example of galling opportunism. If a person is struggling with cardiovascular disease and has been on statins, it's likely the hit to his immune system caused by the statins that landed him in hospital. http://www.spacedoc.net/statins_immune_system.html</description>
		<content:encoded><![CDATA[<p>Thanks for sharing this information?! </p>
<p>Ye gads what a perfect example of galling opportunism. If a person is struggling with cardiovascular disease and has been on statins, it&#8217;s likely the hit to his immune system caused by the statins that landed him in hospital. <a href="http://www.spacedoc.net/statins_immune_system.html" rel="nofollow">http://www.spacedoc.net/statins_immune_system.html</a></p>
]]></content:encoded>
	</item>
	<item>
		<title>By: Degenerative Arthritis</title>
		<link>http://www.pharmalot.com/2009/10/can-cholesterol-pills-really-prevent-flu-deaths/#comment-442603</link>
		<dc:creator>Degenerative Arthritis</dc:creator>
		<pubDate>Fri, 30 Oct 2009 13:56:58 +0000</pubDate>
		<guid isPermaLink="false">http://www.pharmalot.com/?p=19449#comment-442603</guid>
		<description>I rarely post, but I wanted to say thanks for sharing this information.</description>
		<content:encoded><![CDATA[<p>I rarely post, but I wanted to say thanks for sharing this information.</p>
]]></content:encoded>
	</item>
</channel>
</rss>

<!-- Dynamic Page Served (once) in 0.166 seconds -->

