The drugmaker notified the Indiana Department of Workforce Development that it will eliminate 191 sales jobs as part of a company-wide restructuring announced in September that ultimately will result in 5,500 job cuts by the end of 2011, according to the Indiana Business Journal.

The will come from the osteoporosis, diabetes and neuroscience sales forces at Lilly Technology Center South. Their last day of employment is expected to be Dec. 31, Lilly said. However, affected employees will have the opportunity to apply for open positions within the company from Nov. 30 to Dec. 2 and again on Dec. 9 (here is the notice Lilly filed with the state).

Lilly, which had $20 billion in total revenue last year, hopes to shave $1 billion mainly by reducing its worldwide work force from 40,500 to 35,000. Its Oct. 30 notice to the state provides the first indication of which Indiana employees will be affected by the restructuring.