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	<title>Comments on: AstraZeneca Is &#8216;More Sensitive&#8217; About Illegal Marketing</title>
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	<link>http://www.pharmalot.com/2009/12/astrazeneca-is-more-sensitive-about-illegal-marketing/</link>
	<description>News, Comment and Conversation</description>
	<pubDate>Fri, 10 Feb 2012 21:10:20 +0000</pubDate>
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		<title>By: Justice in MI</title>
		<link>http://www.pharmalot.com/2009/12/astrazeneca-is-more-sensitive-about-illegal-marketing/#comment-454014</link>
		<dc:creator>Justice in MI</dc:creator>
		<pubDate>Fri, 25 Dec 2009 18:30:19 +0000</pubDate>
		<guid isPermaLink="false">http://www.pharmalot.com/?p=20586#comment-454014</guid>
		<description>Thanks for a useful response, Atlex.  As you know, JK went through some specifics about no more "chotkes" to docs, transparency issues, need for a stronger FDA (unspecified beyond that), etc.  Anyway, "the system makes it too easy" is just how I'd also say it--and also too tempting, given recently weaker FDA, blockbuster model, pressures re: market share, shareholders, etc..  

So it really comes down to how small or large the number is of actors who do "bad" things, which will, in turn, depend on the situation.  As I understand the DOJ reports, the Neurontin case, as decided in 2004, involved an extensive network at W-L, and would be fairly described as something approaching company-wide.  The recent Pfizer cases (with roots in W-L and Pharmacia) may, indeed, be different.

Anyway, I do think of ethics-in-context, which is why I emphasis the latter when the former is raised by itself.</description>
		<content:encoded><![CDATA[<p>Thanks for a useful response, Atlex.  As you know, JK went through some specifics about no more &#8220;chotkes&#8221; to docs, transparency issues, need for a stronger FDA (unspecified beyond that), etc.  Anyway, &#8220;the system makes it too easy&#8221; is just how I&#8217;d also say it&#8211;and also too tempting, given recently weaker FDA, blockbuster model, pressures re: market share, shareholders, etc..  </p>
<p>So it really comes down to how small or large the number is of actors who do &#8220;bad&#8221; things, which will, in turn, depend on the situation.  As I understand the DOJ reports, the Neurontin case, as decided in 2004, involved an extensive network at W-L, and would be fairly described as something approaching company-wide.  The recent Pfizer cases (with roots in W-L and Pharmacia) may, indeed, be different.</p>
<p>Anyway, I do think of ethics-in-context, which is why I emphasis the latter when the former is raised by itself.</p>
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		<title>By: Atlex</title>
		<link>http://www.pharmalot.com/2009/12/astrazeneca-is-more-sensitive-about-illegal-marketing/#comment-453763</link>
		<dc:creator>Atlex</dc:creator>
		<pubDate>Fri, 25 Dec 2009 02:26:57 +0000</pubDate>
		<guid isPermaLink="false">http://www.pharmalot.com/?p=20586#comment-453763</guid>
		<description>JiM,

I think you inferred more into Kindler's statement than he meant to imply. He does acknowledge bad actions, not just by pharma, but by Big Business overall (remember the time and place of this speech). Importantly, he goes on to say, "Now sometimes this criticism is warranted; sometimes it’s not." To me, the main takeaway from this speech is that bad actions have to be acknowledged and, the consequences of those actions (lost of trust), have to be dealt with.  Are there systemic issues to be dealt with? I think Kindler would say, "yes" but with qualifications. The system makes it too easy for a small number of bad actors to have too great an impact. 

As you can read, my previous statement was a reaction to continual complaints by some posters who always find fault in pharma.

Atlex</description>
		<content:encoded><![CDATA[<p>JiM,</p>
<p>I think you inferred more into Kindler&#8217;s statement than he meant to imply. He does acknowledge bad actions, not just by pharma, but by Big Business overall (remember the time and place of this speech). Importantly, he goes on to say, &#8220;Now sometimes this criticism is warranted; sometimes it’s not.&#8221; To me, the main takeaway from this speech is that bad actions have to be acknowledged and, the consequences of those actions (lost of trust), have to be dealt with.  Are there systemic issues to be dealt with? I think Kindler would say, &#8220;yes&#8221; but with qualifications. The system makes it too easy for a small number of bad actors to have too great an impact. </p>
<p>As you can read, my previous statement was a reaction to continual complaints by some posters who always find fault in pharma.</p>
<p>Atlex</p>
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		<title>By: Justice in MI</title>
		<link>http://www.pharmalot.com/2009/12/astrazeneca-is-more-sensitive-about-illegal-marketing/#comment-453673</link>
		<dc:creator>Justice in MI</dc:creator>
		<pubDate>Thu, 24 Dec 2009 20:15:52 +0000</pubDate>
		<guid isPermaLink="false">http://www.pharmalot.com/?p=20586#comment-453673</guid>
		<description>Atlex--To the degree I have any knowledge of this, I would agree with what you say on the level of individual people who work in the industry.  Indeed, as I've said before, I believe moral compasses are proabably more reliable there than they are in the world I know, academia.

Nevertheless, it is difficult to imagine a statement like Kindler's emerging from academia or even a different industry. Specifically this:

"Across society people believe that the rules meant to bring order to society instead are being manipulated to benefit the rule-makers.  It has become so widespread that having questionable ethics is often seen as the norm.  In fact, doing the right thing now seems quaint and old-fashioned when so many people seem to get away with doing the wrong thing.

People have had enough, and the backlash is real. Its fueling demands for more restrictions on businesses and on government...

Now sometimes this criticism is warranted; sometimes it’s not.  But when the majority of people don’t trust you, they will find a way to force you to change.  So this is where we are.  And it’s up to us to earn back the trust that we’ve lost.

It will take a lot of time and energy, and it won’t happen overnight.  But we have to start by letting people know that we hear them.  This starts by acknowledging where we’ve gone wrong, showing that we’re making real changes..."


Obviously, this is not some blanket "wea culpa."  There are plenty of qualifications and generalizations beyond pharma.  But is it your interpretation that, when Jeff Kindler refers to criticisms that are "warranted," and "acknowledging where we've gone wrong," he is referring only to acknowledging "a few bad actors"?  Or do you think he means, and would you agree, that there are also systemic issues that need to be addressed?</description>
		<content:encoded><![CDATA[<p>Atlex&#8211;To the degree I have any knowledge of this, I would agree with what you say on the level of individual people who work in the industry.  Indeed, as I&#8217;ve said before, I believe moral compasses are proabably more reliable there than they are in the world I know, academia.</p>
<p>Nevertheless, it is difficult to imagine a statement like Kindler&#8217;s emerging from academia or even a different industry. Specifically this:</p>
<p>&#8220;Across society people believe that the rules meant to bring order to society instead are being manipulated to benefit the rule-makers.  It has become so widespread that having questionable ethics is often seen as the norm.  In fact, doing the right thing now seems quaint and old-fashioned when so many people seem to get away with doing the wrong thing.</p>
<p>People have had enough, and the backlash is real. Its fueling demands for more restrictions on businesses and on government&#8230;</p>
<p>Now sometimes this criticism is warranted; sometimes it’s not.  But when the majority of people don’t trust you, they will find a way to force you to change.  So this is where we are.  And it’s up to us to earn back the trust that we’ve lost.</p>
<p>It will take a lot of time and energy, and it won’t happen overnight.  But we have to start by letting people know that we hear them.  This starts by acknowledging where we’ve gone wrong, showing that we’re making real changes&#8230;&#8221;</p>
<p>Obviously, this is not some blanket &#8220;wea culpa.&#8221;  There are plenty of qualifications and generalizations beyond pharma.  But is it your interpretation that, when Jeff Kindler refers to criticisms that are &#8220;warranted,&#8221; and &#8220;acknowledging where we&#8217;ve gone wrong,&#8221; he is referring only to acknowledging &#8220;a few bad actors&#8221;?  Or do you think he means, and would you agree, that there are also systemic issues that need to be addressed?</p>
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		<title>By: Atlex</title>
		<link>http://www.pharmalot.com/2009/12/astrazeneca-is-more-sensitive-about-illegal-marketing/#comment-453625</link>
		<dc:creator>Atlex</dc:creator>
		<pubDate>Thu, 24 Dec 2009 16:46:52 +0000</pubDate>
		<guid isPermaLink="false">http://www.pharmalot.com/?p=20586#comment-453625</guid>
		<description>Former,

As a former marketing director myself and someone who chooses to stay in pharma (albeit in a different capacity), let me assure you that the vast majority of marketers (and everyone else) in pharma have a conscience and a strong moral compass. Just like every other industry (academics, priesthood, journalism, etc.), there are a few bad actors. My observation is that your vehement anti-pharma crusade probably has more to do with your own (perhaps guilty) conscience rather than an evangelical compunction to spread the gospel.

Atlex</description>
		<content:encoded><![CDATA[<p>Former,</p>
<p>As a former marketing director myself and someone who chooses to stay in pharma (albeit in a different capacity), let me assure you that the vast majority of marketers (and everyone else) in pharma have a conscience and a strong moral compass. Just like every other industry (academics, priesthood, journalism, etc.), there are a few bad actors. My observation is that your vehement anti-pharma crusade probably has more to do with your own (perhaps guilty) conscience rather than an evangelical compunction to spread the gospel.</p>
<p>Atlex</p>
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		<title>By: Another former pharma marketing director</title>
		<link>http://www.pharmalot.com/2009/12/astrazeneca-is-more-sensitive-about-illegal-marketing/#comment-453460</link>
		<dc:creator>Another former pharma marketing director</dc:creator>
		<pubDate>Thu, 24 Dec 2009 02:11:09 +0000</pubDate>
		<guid isPermaLink="false">http://www.pharmalot.com/?p=20586#comment-453460</guid>
		<description>Everything the former marketing director states is true. Some companies are more guilty than others. The more "valuable" the patient ($$$), the more egregious. One of my fervent hopes was that "Health-Care Reform" would really focus on cleaning up the pharma and device industries. Doesn't look like that is going to happen - an outcome of very, very strong lobbying and large amounts of cash.</description>
		<content:encoded><![CDATA[<p>Everything the former marketing director states is true. Some companies are more guilty than others. The more &#8220;valuable&#8221; the patient ($$$), the more egregious. One of my fervent hopes was that &#8220;Health-Care Reform&#8221; would really focus on cleaning up the pharma and device industries. Doesn&#8217;t look like that is going to happen - an outcome of very, very strong lobbying and large amounts of cash.</p>
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		<title>By: Justice in MI</title>
		<link>http://www.pharmalot.com/2009/12/astrazeneca-is-more-sensitive-about-illegal-marketing/#comment-453308</link>
		<dc:creator>Justice in MI</dc:creator>
		<pubDate>Wed, 23 Dec 2009 17:13:47 +0000</pubDate>
		<guid isPermaLink="false">http://www.pharmalot.com/?p=20586#comment-453308</guid>
		<description>We've gone around this one before, but it will be a lot easier to "find a conscience" in a different incentive structure.

One of the most revealing documents to emerge in recent years was that one, via the WSJ, from an AZ manager wondering out loud whether or not to "bury" (his word) another study on Seroquel.  Among the reasons not to--he felt they had a relatively good ethical reputation; if they did do it their competitors would "out" them; etc.  

Among the reasons to bury--everyone else was.

Conscience?..."apres vous, Alphonse."</description>
		<content:encoded><![CDATA[<p>We&#8217;ve gone around this one before, but it will be a lot easier to &#8220;find a conscience&#8221; in a different incentive structure.</p>
<p>One of the most revealing documents to emerge in recent years was that one, via the WSJ, from an AZ manager wondering out loud whether or not to &#8220;bury&#8221; (his word) another study on Seroquel.  Among the reasons not to&#8211;he felt they had a relatively good ethical reputation; if they did do it their competitors would &#8220;out&#8221; them; etc.  </p>
<p>Among the reasons to bury&#8211;everyone else was.</p>
<p>Conscience?&#8230;&#8221;apres vous, Alphonse.&#8221;</p>
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		<title>By: elmore</title>
		<link>http://www.pharmalot.com/2009/12/astrazeneca-is-more-sensitive-about-illegal-marketing/#comment-453280</link>
		<dc:creator>elmore</dc:creator>
		<pubDate>Wed, 23 Dec 2009 16:00:05 +0000</pubDate>
		<guid isPermaLink="false">http://www.pharmalot.com/?p=20586#comment-453280</guid>
		<description>To Former Pharma Marketing Director: Everything patrons99 says is true. Bravo, bravo. If only people like you were not "former" but actually running the show. Does anyone in government know or care enough to fix this? Or must it always be lawsuits because people got hurt?</description>
		<content:encoded><![CDATA[<p>To Former Pharma Marketing Director: Everything patrons99 says is true. Bravo, bravo. If only people like you were not &#8220;former&#8221; but actually running the show. Does anyone in government know or care enough to fix this? Or must it always be lawsuits because people got hurt?</p>
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		<title>By: patrons99</title>
		<link>http://www.pharmalot.com/2009/12/astrazeneca-is-more-sensitive-about-illegal-marketing/#comment-453236</link>
		<dc:creator>patrons99</dc:creator>
		<pubDate>Wed, 23 Dec 2009 13:53:54 +0000</pubDate>
		<guid isPermaLink="false">http://www.pharmalot.com/?p=20586#comment-453236</guid>
		<description>Awesome...simply awesome. "It is really about crimes against humanity"..."find a conscience". A wonderfully expressed view (from a former insider). I applaud you, sir! Unless someone like you comes forward, whistleblowers are just "whistling in the wind".</description>
		<content:encoded><![CDATA[<p>Awesome&#8230;simply awesome. &#8220;It is really about crimes against humanity&#8221;&#8230;&#8221;find a conscience&#8221;. A wonderfully expressed view (from a former insider). I applaud you, sir! Unless someone like you comes forward, whistleblowers are just &#8220;whistling in the wind&#8221;.</p>
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		<title>By: Former Pharma Marketing Director</title>
		<link>http://www.pharmalot.com/2009/12/astrazeneca-is-more-sensitive-about-illegal-marketing/#comment-453229</link>
		<dc:creator>Former Pharma Marketing Director</dc:creator>
		<pubDate>Wed, 23 Dec 2009 13:19:35 +0000</pubDate>
		<guid isPermaLink="false">http://www.pharmalot.com/?p=20586#comment-453229</guid>
		<description>It is not just about off label marketing.  It is about putting in bogus clinical trials to prevent patients being accrued to competitive "real" clinical trials.  It is about spending long hours on designing marketing strategy that subverts the truth, fear mongers, and attempts to place obstacles in front of physicians.

It is about buying their way into patient groups, and national organizations and manipulating the government and market to the detriment of patients.

It is about tampering with clinical trial data and making claims based on corrupted clinical trial data.

It is really about crimes against humanity; taking the most vulnerable of our society and using them as profit centers.  

Now they are finding religion?  We are in trouble. Religion is the last place they need to look to fix what they have worked so hard to break.

Ethics - they need to install and listen to an ethics committee that examines and questions the marketing department programs.

So pharma are you listening? Do not find religion, find a conscience!  Or at least a good moral compass......</description>
		<content:encoded><![CDATA[<p>It is not just about off label marketing.  It is about putting in bogus clinical trials to prevent patients being accrued to competitive &#8220;real&#8221; clinical trials.  It is about spending long hours on designing marketing strategy that subverts the truth, fear mongers, and attempts to place obstacles in front of physicians.</p>
<p>It is about buying their way into patient groups, and national organizations and manipulating the government and market to the detriment of patients.</p>
<p>It is about tampering with clinical trial data and making claims based on corrupted clinical trial data.</p>
<p>It is really about crimes against humanity; taking the most vulnerable of our society and using them as profit centers.  </p>
<p>Now they are finding religion?  We are in trouble. Religion is the last place they need to look to fix what they have worked so hard to break.</p>
<p>Ethics - they need to install and listen to an ethics committee that examines and questions the marketing department programs.</p>
<p>So pharma are you listening? Do not find religion, find a conscience!  Or at least a good moral compass&#8230;&#8230;</p>
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		<title>By: patrons99</title>
		<link>http://www.pharmalot.com/2009/12/astrazeneca-is-more-sensitive-about-illegal-marketing/#comment-453222</link>
		<dc:creator>patrons99</dc:creator>
		<pubDate>Wed, 23 Dec 2009 13:05:27 +0000</pubDate>
		<guid isPermaLink="false">http://www.pharmalot.com/?p=20586#comment-453222</guid>
		<description>Elmore,

You have expressed it perfectly...sickness sells...wellness doesn’t. It’s become a sickness industry. Healthcare reform? It’s not going to happen. The chairs just got rearranged, that’s all. Pharma and the fat cats (a whole array of parasites, e.g., insurance companies), will continue to gorge on the public.  Don’t hold your breath, waiting for someone to say, “wait, this is immoral”. We are all “sitting ducks”. Drug safety and the public “health” have been savaged. It’s a disgrace.</description>
		<content:encoded><![CDATA[<p>Elmore,</p>
<p>You have expressed it perfectly&#8230;sickness sells&#8230;wellness doesn’t. It’s become a sickness industry. Healthcare reform? It’s not going to happen. The chairs just got rearranged, that’s all. Pharma and the fat cats (a whole array of parasites, e.g., insurance companies), will continue to gorge on the public.  Don’t hold your breath, waiting for someone to say, “wait, this is immoral”. We are all “sitting ducks”. Drug safety and the public “health” have been savaged. It’s a disgrace.</p>
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