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	<title>Comments on: The Cholesterol Debate And Journal Disclosures</title>
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	<link>http://www.pharmalot.com/2010/06/the-cholesterol-debate-and-journal-disclosures/</link>
	<description>News, Comment and Conversation</description>
	<pubDate>Fri, 10 Feb 2012 20:38:40 +0000</pubDate>
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		<title>By: Marilyn Mann</title>
		<link>http://www.pharmalot.com/2010/06/the-cholesterol-debate-and-journal-disclosures/#comment-527744</link>
		<dc:creator>Marilyn Mann</dc:creator>
		<pubDate>Sun, 15 Aug 2010 13:09:03 +0000</pubDate>
		<guid isPermaLink="false">http://www.pharmalot.com/?p=24398#comment-527744</guid>
		<description>Dr. de Lorgeril and his co-author Patricia Salen do not seem to be opposed to industry-funded research in general.  They are on the scientific advisory board for The Columbus Paradigm Institute SA, a BNLfood Group (Belovo) company.

http://www.columbus-concept.com/aboutus/aboutus.php?cat_ID=2

The purposes of the SAB include:

•review and evaluate studies in progress funded by Belovo
•consider new proposals
•generate research proposals
•develop collaborative research
•review statements developed by Belovo for scientific accuracy (i.e. Common Statement)
•ensure that marketing is based on scientific concepts and principles
•establish an international network of scientists for the presentation of the scientific aspects of the Columbus Concept to the press 

BNLfood Group (Belovo) produces foods such as eggs with a high Omega-3 content.  So, naturally, BNLfood Group is interested in funding research on its products.

http://www.bnlfood.com/

So, Dr. de Lorgeril and Ms. Salen are apparently fine with studies funded by industries that they approve of.</description>
		<content:encoded><![CDATA[<p>Dr. de Lorgeril and his co-author Patricia Salen do not seem to be opposed to industry-funded research in general.  They are on the scientific advisory board for The Columbus Paradigm Institute SA, a BNLfood Group (Belovo) company.</p>
<p><a href="http://www.columbus-concept.com/aboutus/aboutus.php?cat_ID=2" rel="nofollow">http://www.columbus-concept.com/aboutus/aboutus.php?cat_ID=2</a></p>
<p>The purposes of the SAB include:</p>
<p>•review and evaluate studies in progress funded by Belovo<br />
•consider new proposals<br />
•generate research proposals<br />
•develop collaborative research<br />
•review statements developed by Belovo for scientific accuracy (i.e. Common Statement)<br />
•ensure that marketing is based on scientific concepts and principles<br />
•establish an international network of scientists for the presentation of the scientific aspects of the Columbus Concept to the press </p>
<p>BNLfood Group (Belovo) produces foods such as eggs with a high Omega-3 content.  So, naturally, BNLfood Group is interested in funding research on its products.</p>
<p><a href="http://www.bnlfood.com/" rel="nofollow">http://www.bnlfood.com/</a></p>
<p>So, Dr. de Lorgeril and Ms. Salen are apparently fine with studies funded by industries that they approve of.</p>
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		<title>By: Lorraine Johnson</title>
		<link>http://www.pharmalot.com/2010/06/the-cholesterol-debate-and-journal-disclosures/#comment-512664</link>
		<dc:creator>Lorraine Johnson</dc:creator>
		<pubDate>Tue, 13 Jul 2010 18:41:10 +0000</pubDate>
		<guid isPermaLink="false">http://www.pharmalot.com/?p=24398#comment-512664</guid>
		<description>The issue of disclosing non-financial conflicts of interests is new.  IOM has interesting book on conflicts exploring all this in depth. (Institute of Medicine (Committee on Conflict of Interest in Medical Research E, and Practice), . Conflict of interest in medical research, education, and practice. Washington, DC: National Academies Press., 2009.) It's available on line. The reason that non-financial are not normally considered disclosable is that the "line drawing" exercise inherent in COI management becomes quite difficult--everyone has a bias. 

COI requires a different approach from bias.   For instance, the IOM(ish) answer to financial conflicts of interest on guidelines panels would be to avoid them entirely or barring that limit them (no more than 20% on panel say) and contain them (no chairmanships, no writing, maybe no voting).  

The answer to bias on a guidelines panel, on the other hand, is to make sure that stakeholders are represented and that views are not suppressed by dominant players.  This is to ensure that treatment options are preserved and that where science is lacking and viewpoints are divided the default is to clinical judgment and patient autonomy.

DOI  Activist on minority side of medical debate in Lyme disease.</description>
		<content:encoded><![CDATA[<p>The issue of disclosing non-financial conflicts of interests is new.  IOM has interesting book on conflicts exploring all this in depth. (Institute of Medicine (Committee on Conflict of Interest in Medical Research E, and Practice), . Conflict of interest in medical research, education, and practice. Washington, DC: National Academies Press., 2009.) It&#8217;s available on line. The reason that non-financial are not normally considered disclosable is that the &#8220;line drawing&#8221; exercise inherent in COI management becomes quite difficult&#8211;everyone has a bias. </p>
<p>COI requires a different approach from bias.   For instance, the IOM(ish) answer to financial conflicts of interest on guidelines panels would be to avoid them entirely or barring that limit them (no more than 20% on panel say) and contain them (no chairmanships, no writing, maybe no voting).  </p>
<p>The answer to bias on a guidelines panel, on the other hand, is to make sure that stakeholders are represented and that views are not suppressed by dominant players.  This is to ensure that treatment options are preserved and that where science is lacking and viewpoints are divided the default is to clinical judgment and patient autonomy.</p>
<p>DOI  Activist on minority side of medical debate in Lyme disease.</p>
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		<title>By: NP</title>
		<link>http://www.pharmalot.com/2010/06/the-cholesterol-debate-and-journal-disclosures/#comment-512524</link>
		<dc:creator>NP</dc:creator>
		<pubDate>Mon, 12 Jul 2010 00:39:20 +0000</pubDate>
		<guid isPermaLink="false">http://www.pharmalot.com/?p=24398#comment-512524</guid>
		<description>Malcolm Kendrick, do you earn royalties on your book?  If so, why would this not be considered a "conflict of interest"?  Would it be fair to say that if the controversy over statins and/or cholesterol were to die down, there may be less interest in your book?</description>
		<content:encoded><![CDATA[<p>Malcolm Kendrick, do you earn royalties on your book?  If so, why would this not be considered a &#8220;conflict of interest&#8221;?  Would it be fair to say that if the controversy over statins and/or cholesterol were to die down, there may be less interest in your book?</p>
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		<title>By: Marilyn Mann</title>
		<link>http://www.pharmalot.com/2010/06/the-cholesterol-debate-and-journal-disclosures/#comment-512225</link>
		<dc:creator>Marilyn Mann</dc:creator>
		<pubDate>Fri, 09 Jul 2010 14:43:34 +0000</pubDate>
		<guid isPermaLink="false">http://www.pharmalot.com/?p=24398#comment-512225</guid>
		<description>More on Dr. de Lorgeril:

http://cardiobrief.org/2010/07/08/authors-of-jupiter-attack-committed-self-plagiarism/</description>
		<content:encoded><![CDATA[<p>More on Dr. de Lorgeril:</p>
<p><a href="http://cardiobrief.org/2010/07/08/authors-of-jupiter-attack-committed-self-plagiarism/" rel="nofollow">http://cardiobrief.org/2010/07/08/authors-of-jupiter-attack-committed-self-plagiarism/</a></p>
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		<title>By: Josh</title>
		<link>http://www.pharmalot.com/2010/06/the-cholesterol-debate-and-journal-disclosures/#comment-511998</link>
		<dc:creator>Josh</dc:creator>
		<pubDate>Wed, 07 Jul 2010 12:52:07 +0000</pubDate>
		<guid isPermaLink="false">http://www.pharmalot.com/?p=24398#comment-511998</guid>
		<description>Mr. Barker,

Obviously you are not a frequent visitor to this site or you would know that Ed is certainly not in the employ of pharma companies.  He is a journalist asking a very fair question, so no need to be so defensive.

I just noted an interesting dynamic on this site...someone questions something anti-pharma, they are labeled "shills for the industry", but when the shoe is on the other foot, people are mounting the .50 cal.</description>
		<content:encoded><![CDATA[<p>Mr. Barker,</p>
<p>Obviously you are not a frequent visitor to this site or you would know that Ed is certainly not in the employ of pharma companies.  He is a journalist asking a very fair question, so no need to be so defensive.</p>
<p>I just noted an interesting dynamic on this site&#8230;someone questions something anti-pharma, they are labeled &#8220;shills for the industry&#8221;, but when the shoe is on the other foot, people are mounting the .50 cal.</p>
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		<title>By: Jeff Cable</title>
		<link>http://www.pharmalot.com/2010/06/the-cholesterol-debate-and-journal-disclosures/#comment-511989</link>
		<dc:creator>Jeff Cable</dc:creator>
		<pubDate>Wed, 07 Jul 2010 08:28:41 +0000</pubDate>
		<guid isPermaLink="false">http://www.pharmalot.com/?p=24398#comment-511989</guid>
		<description>D.O.I: I am unwilling to support or acknowledge any 'research' which was funded by individuals or institutions which have any vested interest in manipulating the outcome, usually to improve the prospect of making more pharmaceutical sales... either for the usual quid pro quo provided by pharmaceutical companies or where the 'research' is a blatant advertorial for the product and was based upon junk science.

The obvious solution (to questionable 'research' being proffered as novel and compelling) is to refuse to accept papers that were funded by vested interests. Advertising revenues for medical journals may suffer as a result but integrity is just like virginity, when it is lost, there is no recovery. Be in no doubt; several fake journals, published by Elsevier, were an indicator of pharmaceutical company intrusion into medical practice and clinical judgement.

Prospective authors, who are in the paid employ of pharmaceutical companies, should automatically forfeit their right to submit research to medical journals... by dint of a career choice which they have made by accepting honoraria and more, from the pharmaceutical industry. 

As for the potential conflict of interest in holding a contrarian viewpoint... piffle! Where there is no opportunity for pecuniary gain, it is an irrelevance as to what school of thought a person subscribes. The hope is always that they will believe in the value of independent thought and testing their beliefs.</description>
		<content:encoded><![CDATA[<p>D.O.I: I am unwilling to support or acknowledge any &#8216;research&#8217; which was funded by individuals or institutions which have any vested interest in manipulating the outcome, usually to improve the prospect of making more pharmaceutical sales&#8230; either for the usual quid pro quo provided by pharmaceutical companies or where the &#8216;research&#8217; is a blatant advertorial for the product and was based upon junk science.</p>
<p>The obvious solution (to questionable &#8216;research&#8217; being proffered as novel and compelling) is to refuse to accept papers that were funded by vested interests. Advertising revenues for medical journals may suffer as a result but integrity is just like virginity, when it is lost, there is no recovery. Be in no doubt; several fake journals, published by Elsevier, were an indicator of pharmaceutical company intrusion into medical practice and clinical judgement.</p>
<p>Prospective authors, who are in the paid employ of pharmaceutical companies, should automatically forfeit their right to submit research to medical journals&#8230; by dint of a career choice which they have made by accepting honoraria and more, from the pharmaceutical industry. </p>
<p>As for the potential conflict of interest in holding a contrarian viewpoint&#8230; piffle! Where there is no opportunity for pecuniary gain, it is an irrelevance as to what school of thought a person subscribes. The hope is always that they will believe in the value of independent thought and testing their beliefs.</p>
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		<title>By: Michael Barker</title>
		<link>http://www.pharmalot.com/2010/06/the-cholesterol-debate-and-journal-disclosures/#comment-511987</link>
		<dc:creator>Michael Barker</dc:creator>
		<pubDate>Wed, 07 Jul 2010 05:55:13 +0000</pubDate>
		<guid isPermaLink="false">http://www.pharmalot.com/?p=24398#comment-511987</guid>
		<description>Identifying what school of thought one comes fromf thought, ad hoc or not, to my knowledge has never been required for discourse. If this is a new standard, Mr. Silverman, who authored this article should give his. I would, as well, require that those who have authored other papers on diet and nutrition do so as well. What is good for the goose is good for the gander.</description>
		<content:encoded><![CDATA[<p>Identifying what school of thought one comes fromf thought, ad hoc or not, to my knowledge has never been required for discourse. If this is a new standard, Mr. Silverman, who authored this article should give his. I would, as well, require that those who have authored other papers on diet and nutrition do so as well. What is good for the goose is good for the gander.</p>
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		<title>By: Malcolm Kendrick</title>
		<link>http://www.pharmalot.com/2010/06/the-cholesterol-debate-and-journal-disclosures/#comment-511893</link>
		<dc:creator>Malcolm Kendrick</dc:creator>
		<pubDate>Mon, 05 Jul 2010 13:40:53 +0000</pubDate>
		<guid isPermaLink="false">http://www.pharmalot.com/?p=24398#comment-511893</guid>
		<description>D.O.I. (disclosure of interest)

My D.O.I is that I am also a member of thincs.

A conflict of interest is something that might mean you are biased towards something due to financial pressure. However, it is hardly a conflict of interest for someone who does not believe in the diet/heart cholesterol hypothesis to write an article critical of the hypothesis. What are they supposed to do? Never write anything. Write articles in conflict with their own views?

As proposed at the start of this message. It may be of interest to people to know what the views of the author are, on the subject in hand.

But having a point of view is very different from being paid hundreds of thousands of dollars a year by a company with a vested financial interest in a certain outcome</description>
		<content:encoded><![CDATA[<p>D.O.I. (disclosure of interest)</p>
<p>My D.O.I is that I am also a member of thincs.</p>
<p>A conflict of interest is something that might mean you are biased towards something due to financial pressure. However, it is hardly a conflict of interest for someone who does not believe in the diet/heart cholesterol hypothesis to write an article critical of the hypothesis. What are they supposed to do? Never write anything. Write articles in conflict with their own views?</p>
<p>As proposed at the start of this message. It may be of interest to people to know what the views of the author are, on the subject in hand.</p>
<p>But having a point of view is very different from being paid hundreds of thousands of dollars a year by a company with a vested financial interest in a certain outcome</p>
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		<title>By: Uffe Ravnskov</title>
		<link>http://www.pharmalot.com/2010/06/the-cholesterol-debate-and-journal-disclosures/#comment-511883</link>
		<dc:creator>Uffe Ravnskov</dc:creator>
		<pubDate>Mon, 05 Jul 2010 08:09:45 +0000</pubDate>
		<guid isPermaLink="false">http://www.pharmalot.com/?p=24398#comment-511883</guid>
		<description>The consequence
If Michel de Lorgeril and Tomohito Hamazaki should have told about their membership of THINCS, then all scientists who present a new hypothesis or explanation must declare a conflict of interest: I do not believe in the current view on this issue.
Uffe Ravnskov
Spokesman of THINCS</description>
		<content:encoded><![CDATA[<p>The consequence<br />
If Michel de Lorgeril and Tomohito Hamazaki should have told about their membership of THINCS, then all scientists who present a new hypothesis or explanation must declare a conflict of interest: I do not believe in the current view on this issue.<br />
Uffe Ravnskov<br />
Spokesman of THINCS</p>
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		<title>By: Kaia</title>
		<link>http://www.pharmalot.com/2010/06/the-cholesterol-debate-and-journal-disclosures/#comment-511359</link>
		<dc:creator>Kaia</dc:creator>
		<pubDate>Thu, 01 Jul 2010 18:52:16 +0000</pubDate>
		<guid isPermaLink="false">http://www.pharmalot.com/?p=24398#comment-511359</guid>
		<description>De Lorgeril's research and publications are related to the Mediterranean diet which does not endorse a high animal fat content. This research looks at what diet and non-drug interventions can accomplish in cardioprotection and has found health benefits independent of targeted cholesterol levels. Many others including popular analysts of diet and health as diverse as Michael Pollan and Gary Taubes have argued against the relevance of dietary cholesterol without being labeled cultists.
Perhaps de Lorgeril's association with THINCS should be deemed a commendable example of collegiality considering their differing views on diet. 
Or perhaps, those who adhere to a guilt-by-association model of COI desire even more stringent parameters.Should authors disclose what they had for lunch?</description>
		<content:encoded><![CDATA[<p>De Lorgeril&#8217;s research and publications are related to the Mediterranean diet which does not endorse a high animal fat content. This research looks at what diet and non-drug interventions can accomplish in cardioprotection and has found health benefits independent of targeted cholesterol levels. Many others including popular analysts of diet and health as diverse as Michael Pollan and Gary Taubes have argued against the relevance of dietary cholesterol without being labeled cultists.<br />
Perhaps de Lorgeril&#8217;s association with THINCS should be deemed a commendable example of collegiality considering their differing views on diet.<br />
Or perhaps, those who adhere to a guilt-by-association model of COI desire even more stringent parameters.Should authors disclose what they had for lunch?</p>
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