Comments on: Will Prescription Diet Pills Become Hot - Again?

By: Ellen Williams

Ellen Williams — Tue, 26 Oct 2010 18:58:58 +0000

I think phen-phen was wonderful. I lost 30 pounds & have kept it off all these years later. It was supposed to be used for 3 months. The people who kept going to different doctors to get more & more ruined it for everyone. If you’re overly obese, your heart is going to give out. A few abusers ruined the chances for thousands - & then blamed companies.

By: Theresa

Theresa — Mon, 30 Aug 2010 21:00:39 +0000

I think that this medication that the FDA may approve called Lorcaserin could be a fairly effective treatment, however as with any drug there are side effects even if low. Regardless more here http://www.lorcaserinpill.com/

By: qiangqiang

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By: Justice in MI

Justice in MI — Sat, 03 Jul 2010 00:02:11 +0000

Good point, Salmon.

Beyond that, I appreciated Vet’s response, and I certainly respect confidentiality agreements and other good reasons to post with care.

Also, I think it’s a tribute to Ed and Pharmalot that the blog is followed closely.

Happy holiday to Canadians, Americans, and anyone else who’s celebrating!

By: Carmen

Carmen — Fri, 02 Jul 2010 20:58:21 +0000

What’s fascinating about Arena’s lorcaserin is that it’s actually got the same biological target as fenfluramine. Arena designed the molecule to be more selective for the target, which they thought might lead to a better safety profile. So far, that seems to be the case.

http://cenblog.org/the-haystack/tag/lorcaserin/

I have to think that people are salivating at the idea of combining phentermine and lorcaserin, if the latter’s approved. (New Phen-Fen? Lorca-Phen? anyone?) But the tests on the combo aren’t there and aren’t likely to happen..

By: Salmon

Salmon — Fri, 02 Jul 2010 20:26:51 +0000

No one would have worked on Phen-Fen. It wasn’t a studied or an approved combination. It was that dex-fenfluramine (Redux) was used (and pushed) off-label in combination with phenteramine and that was what exaserbated the problem that occurred with each of them singly but at lower rates. Although as I recall with dex-fenfluramine or fenfluramine alone there is evidence of pulmonary arterial hypertension (PAH) already developing on 2D echo in 30% of patients after 3 months of use.

Salmon

By: GC

GC — Fri, 02 Jul 2010 19:50:25 +0000

11 minutes from JiM’s post to the chill note from “Searching.”

What more do we need to know?

By: k

Fri, 02 Jul 2010 02:57:16 +0000

Topiramate is a great drug for weight loss. It’s one of the few psych meds I’ve been prescribed that doesn’t cause weight gain. It isn’t effective for bipolar disorder and it causes cognitivr difficulties (CRS - can’t remember s**t). Adderall for my ADD didn’t counteract the negative effects of “Dopamax”. I pity those who “ask their dr” about Qnexa!

By: pharmavet

pharmavet — Fri, 02 Jul 2010 00:04:50 +0000

JiM, I’m not sure if my Confidentiality Agreement is still in force, but I will say that I did not work on Fen-Phen. I did participate once in a roundtable discussion when Orlistat (Xenical) was first introduced, and with respect to gastrointestinal side effects, as Searching 2000 said, perhaps some things are best left out of a public forum

By: Searching2000

Searching2000 — Thu, 01 Jul 2010 20:59:37 +0000

Vet:
With all due respect to (and “for”) Justice, some questions are best left unanswered in a public forum.